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CC 1 Midterms > Plasma Proteins (TOPIC 2 PROTEINS) > Flashcards

Plasma Proteins (TOPIC 2 PROTEINS) Flashcards

1
Q

Contain fibrinogen

A

Plasma proteins

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2
Q

No fibrinogen (consumed during coagulation)
6 % decrease in total protein content due to absence of fibrinogen.

A

Serum proteins

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3
Q

Composed 60% on the Total Protein

A

Albumin

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4
Q

Composed 40% on the Total Protein

A

Globulin

Alpha
Beta
Gamma

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5
Q

Examples of Prealbumin in plasma proteins electrophoretic mobility

A

Transthyretin,
thyroxine binding pre albumin

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6
Q

Examples of Albumin in plasma proteins electrophoretic mobility

A

Albumin

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7
Q

Examples of Alpha 1 globulin in plasma proteins electrophoretic mobility

A

Alpha1 anti-trypsin,
AFP (alpha feto protein),
alpha lipoprotein,
alpha-1-acid glycoprotein,
alpha-1-antichemotrypsin,
prothrombin

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8
Q

Examples of alpha 2 globulin in plasma proteins electrophoretic mobility

A

Ceruloplasmin,
haptoglobin,
alpha-2-macroglobulin,
erythropoietin

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9
Q

Examples of Beta globulin in plasma proteins electrophoretic mobility

A

Transferrin,
hemopexin,
beta-2-macroglobulin,
complement components,
fibrinogen,
VLDL,
LDL,
C-reactive protein (CRP)

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10
Q

Examples of Gamma globulin in plasma proteins electrophoretic mobility

A

Immunoglobulins (antibodies)

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11
Q

majority of Alpha 1 globulin

A

Alpha 1 anti-trypsin-

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12
Q

majority of alpha 2 globulin

A

Alpha 2 macroglobulin

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13
Q

majority of beta globulin

A

Transfeerrin

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14
Q

Also called transthyretin.

A

Prealbumin

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15
Q

Prealbumin aka

A

Transthyretin

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16
Q

Migrates faster than albumin. 2nd most predominant protein in CSF.

A

Prealbumin

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17
Q

Carrier protein for thyroid hormones specifically thyroid binding prealbumin (TBPA)

A

Prealbumin

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18
Q

The most sensitive indicator for poor nutritional status (< 10 mg/dl)
Life span: 2 days

A

Prealbumin

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19
Q

Greek word “albus” means white. Based on white precipitation developed when acidic urine is heated.

A

Albumin

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20
Q

Most predominant in plasma proteins

A

Albumin

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21
Q

Produced form the liver, Life span: 20 days

A

Albumin

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22
Q

Major transport carrier of most substances.

A

Albumin

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23
Q

Regulates the oncotic pressure (colloidal osmotic pressure)

A

Albumin

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24
Q

Albumin Increased in?

A

Dehydration
Prolong Torniquet Application

25
Albumin Decreased in?
Inflammation Liver Diseases Kidney Diseas Gastrointestinal loss Malnutrition Burn Injury Edema and acites
26
Globulins- conjugated proteins consist of:
Alpha1 globulin Alpha-2 globulin Beta globulin Gamma globulin
27
Plasma protein Alpha-1-globulin Clinical Significance (elevated)
Infections and inflammatory disease such as Acute hepatitis
28
Plasma protein Alpha-2-globulin Clinical Significance (elevated)
Nephrotic syndrome, rheumatoid arthritis, Systemic lupus erythematosus (SLE), after myocardial infarction.
29
Plasma protein Beta globulin Clinical Significance (elevated)
Hyperlipidemia
30
Plasma protein Gamma globulin Clinical Significance (elevated)
Polyclonal gammopathy, viral hepatitis, rheumatoid arthritis, leukemia lymphomas Decrease in Hodgkin’s disease
31
is a glycoprotein, inhibitors of plasma serine proteases. Deficiency leads to emphysema (chronic obstructive pulmonary disease).
α1-antitrypsin(majority)-
32
high carbohydrate content, carrier for steroid hormones. Elevated in neonates with bacterial infection
α1 acid glycoprotein-
33
also known as SERPIN major plasma serine proteinase inhibitor.
Alpha-1-antichymotrypsin
34
precursor of thrombin necessary for coagulation.
Prothrombin
35
synthesized in embryo and fetus. Elevated in Neural tube defect an low in Down syndrome. Serves as a tumor marker.
Alpha feto protein (AFP)-
36
transport protein for Copper (95 %), associated with Wilson’s disease
Ceruloplasmin
37
transport protein for free hemoglobin. (decrease in hemolytic anemia)
Haptoglobin
38
transport carrier for zinc in plasma and as a protease inhibitor. Elevated in diabetes, nephrotic syndrome and liver disease.
a2 macroglobulin
39
hormone produced in the kidney for erythropoiesis
Erythropoietin
40
Also known as Siderophilin, a transport protein for Iron. Accumulation iron leads to hemosiderin formation which can be stained with Perl’s Prussian blue.
Transferrin
41
transport protein for heme. (decrease in hemolytic anemia)
Hemopexin
42
part of Major histocompatility complex (MHC).
β2 macroglobulin-
43
precursor of fibrin involve in coagulation. Majority of coagulation factors.
Fibrinogen-
44
humoral immune response.
Complement factors-
45
carrier of lipids
VLDL and LDL-
46
precipitates C substance of pneumococci. Used as indicator for non specific inflammation.
C- reactive protein (CRP)-
47
A glycoprotein produced by plasma cells.
IgG IgM IgA IgE IgD
48
Other plasma proteins
Bence jones protein Myoglobin Troponin Cystatin C Amyloids Cross-linked C-telopeptides Adiponectin B-Trace protein (BTP) Fibronectin Brain Netriuretic Peptide (BNP)
49
excreted in the urine by patient with Multiple myeloma.
Bence jones protein
50
used as marker for myocardial infarction (not specific)
Myoglobin
51
specific biomarker for Myocardial infarction.
Troponin
52
cysteine proteinase inhibitor, used to evaluate of renal function test or creatinine clearance test. A sensitive biomarker for diabetic kidney disease.
Cystatin C
53
insoluble fibrous protein aggregates due alteration in secondary structure. Deposition to tissues is called Amyloidosis, stained with Congo red.
Amyloids
54
biomarkers for bone resorption, used for clinical assessment of osteoarthritis
Cross-linked C-Telopeptides
55
produce by adipocytes. Low level indicates high risk to DM 2 and heart disease.
Adiponectin
56
brain specific proteins, biomarker for CSF leakage due to head trauma inflammation or tumor.
β-Trace protein (BTP)-
57
secreted during pregnancy, indicator for possible premature delivery for congestive heart failure
Fibronectin
58
inhibits angiotensin II and norepinephrine synthesis. Used as a diagnostic marker for heart failure.
Brain Natriuretic Peptide (BNP)-

CC 1 Midterms (14 decks)

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