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1. CC 1 Midterms > Plasma Proteins (TOPIC 2 PROTEINS) > Flashcards

Plasma Proteins (TOPIC 2 PROTEINS) Flashcards

1
Q

Contain fibrinogen

A

Plasma proteins

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2
Q

No fibrinogen (consumed during coagulation)
6 % decrease in total protein content due to absence of fibrinogen.

A

Serum proteins

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3
Q

Composed 60% on the Total Protein

A

Albumin

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4
Q

Composed 40% on the Total Protein

A

Globulin

Alpha
Beta
Gamma

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5
Q

Examples of Prealbumin in plasma proteins electrophoretic mobility

A

Transthyretin,
thyroxine binding pre albumin

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6
Q

Examples of Albumin in plasma proteins electrophoretic mobility

A

Albumin

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7
Q

Examples of Alpha 1 globulin in plasma proteins electrophoretic mobility

A

Alpha1 anti-trypsin,
AFP (alpha feto protein),
alpha lipoprotein,
alpha-1-acid glycoprotein,
alpha-1-antichemotrypsin,
prothrombin

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8
Q

Examples of alpha 2 globulin in plasma proteins electrophoretic mobility

A

Ceruloplasmin,
haptoglobin,
alpha-2-macroglobulin,
erythropoietin

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9
Q

Examples of Beta globulin in plasma proteins electrophoretic mobility

A

Transferrin,
hemopexin,
beta-2-macroglobulin,
complement components,
fibrinogen,
VLDL,
LDL,
C-reactive protein (CRP)

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10
Q

Examples of Gamma globulin in plasma proteins electrophoretic mobility

A

Immunoglobulins (antibodies)

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11
Q

majority of Alpha 1 globulin

A

Alpha 1 anti-trypsin-

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12
Q

majority of alpha 2 globulin

A

Alpha 2 macroglobulin

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13
Q

majority of beta globulin

A

Transfeerrin

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14
Q

Also called transthyretin.

A

Prealbumin

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15
Q

Prealbumin aka

A

Transthyretin

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16
Q

Migrates faster than albumin. 2nd most predominant protein in CSF.

A

Prealbumin

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17
Q

Carrier protein for thyroid hormones specifically thyroid binding prealbumin (TBPA)

A

Prealbumin

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18
Q

The most sensitive indicator for poor nutritional status (< 10 mg/dl)
Life span: 2 days

A

Prealbumin

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19
Q

Greek word “albus” means white. Based on white precipitation developed when acidic urine is heated.

A

Albumin

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20
Q

Most predominant in plasma proteins

A

Albumin

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21
Q

Produced form the liver, Life span: 20 days

A

Albumin

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22
Q

Major transport carrier of most substances.

A

Albumin

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23
Q

Regulates the oncotic pressure (colloidal osmotic pressure)

A

Albumin

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24
Q

Albumin Increased in?

A

Dehydration
Prolong Torniquet Application

25
Q

Albumin Decreased in?

A

Inflammation
Liver Diseases
Kidney Diseas
Gastrointestinal loss
Malnutrition
Burn Injury
Edema and acites

26
Q

Globulins- conjugated proteins consist of:

A

Alpha1 globulin
Alpha-2 globulin
Beta globulin
Gamma globulin

27
Q

Plasma protein Alpha-1-globulin Clinical Significance (elevated)

A

Infections and inflammatory disease such as
Acute hepatitis

28
Q

Plasma protein Alpha-2-globulin Clinical Significance (elevated)

A

Nephrotic syndrome,
rheumatoid arthritis,
Systemic lupus erythematosus (SLE),
after myocardial infarction.

29
Q

Plasma protein Beta globulin Clinical Significance (elevated)

A

Hyperlipidemia

30
Q

Plasma protein Gamma globulin Clinical Significance (elevated)

A

Polyclonal gammopathy,
viral hepatitis,
rheumatoid arthritis,
leukemia
lymphomas
Decrease in Hodgkin’s disease

31
Q

is a glycoprotein, inhibitors of plasma serine proteases. Deficiency leads to emphysema (chronic obstructive pulmonary disease).

A

α1-antitrypsin(majority)-

32
Q

high carbohydrate content, carrier for steroid hormones. Elevated in neonates with bacterial infection

A

α1 acid glycoprotein-

33
Q

also known as SERPIN major plasma serine proteinase inhibitor.

A

Alpha-1-antichymotrypsin

34
Q

precursor of thrombin necessary for coagulation.

A

Prothrombin

35
Q

synthesized in embryo and fetus. Elevated in Neural tube defect an low in Down syndrome. Serves as a tumor marker.

A

Alpha feto protein (AFP)-

36
Q

transport protein for Copper (95 %), associated with Wilson’s disease

A

Ceruloplasmin

37
Q

transport protein for free hemoglobin. (decrease in hemolytic anemia)

A

Haptoglobin

38
Q

transport carrier for zinc in plasma and as a protease inhibitor. Elevated in diabetes, nephrotic syndrome and liver disease.

A

a2 macroglobulin

39
Q

hormone produced in the kidney for erythropoiesis

A

Erythropoietin

40
Q

Also known as Siderophilin, a transport protein for Iron. Accumulation iron leads to hemosiderin formation which can be stained with Perl’s Prussian blue.

A

Transferrin

41
Q

transport protein for heme. (decrease in hemolytic anemia)

A

Hemopexin

42
Q

part of Major histocompatility complex (MHC).

A

β2 macroglobulin-

43
Q

precursor of fibrin involve in coagulation. Majority of coagulation factors.

A

Fibrinogen-

44
Q

humoral immune response.

A

Complement factors-

45
Q

carrier of lipids

A

VLDL and LDL-

46
Q

precipitates C substance of pneumococci. Used as indicator for non specific inflammation.

A

C- reactive protein (CRP)-

47
Q

A glycoprotein produced by plasma cells.

A

IgG
IgM
IgA
IgE
IgD

48
Q

Other plasma proteins

A

Bence jones protein
Myoglobin
Troponin
Cystatin C
Amyloids
Cross-linked C-telopeptides
Adiponectin
B-Trace protein (BTP)
Fibronectin
Brain Netriuretic Peptide (BNP)

49
Q

excreted in the urine by patient with Multiple myeloma.

A

Bence jones protein

50
Q

used as marker for myocardial infarction (not specific)

A

Myoglobin

51
Q

specific biomarker for Myocardial infarction.

A

Troponin

52
Q

cysteine proteinase inhibitor, used to evaluate of renal function test or creatinine clearance test. A sensitive biomarker for diabetic kidney disease.

A

Cystatin C

53
Q

insoluble fibrous protein aggregates due alteration in secondary structure. Deposition to tissues is called Amyloidosis, stained with Congo red.

A

Amyloids

54
Q

biomarkers for bone resorption, used for clinical assessment of osteoarthritis

A

Cross-linked C-Telopeptides

55
Q

produce by adipocytes. Low level indicates high risk to DM 2 and heart disease.

A

Adiponectin

56
Q

brain specific proteins, biomarker for CSF leakage due to head trauma inflammation or tumor.

A

β-Trace protein (BTP)-

57
Q

secreted during pregnancy, indicator for possible premature delivery for congestive heart failure

A

Fibronectin

58
Q

inhibits angiotensin II and norepinephrine synthesis. Used as a diagnostic marker for heart failure.

A

Brain Natriuretic Peptide (BNP)-

1. CC 1 Midterms (14 decks)

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