Lipids and Lipids Metabolism (TOPIC 1) Flashcards
Also known as Fats.
Lipids
Lipids or Fats contain?
Carbon, Hydrogen and Oxygen (CHO).
Water insoluble hence they are transported in the blood by lipoproteins.
Lipids
1 gram of fat=
9 kilocalories.
Rich source of energy compared to carbohydrates.
Lipids
Forms the structural membrane of the cells (phospholipid bilayer).
Lipids
Precursors of hormone production (steroid hormones).
Lipids
Types of lipids
Fatty acids
Triglycerides
Phospholipids
Cholesterol
The building blocks of lipids.
Fatty acids
Consist of hydrocarbons with COOH (carboxyl) terminal group.
Fatty acids
Found in triglycerides, cholesterol and phospholipids.
Fatty acids
Fatty Acids exist in 2 forms in the blood
Fatty Acid Esters
Free Fatty Acids
bound to triglycerides, cholesterol and phospholipids.
Fatty acid esters (majority)-
not bound to any molecule and transported by albumin.
Free fatty acids (unesterified)-
Types of fatty acids
Saturated fatty acids-
Unsaturated fatty acids-
fatty acids with NO double bond. Linear hydrocarbon chain.
Saturated fatty acids-
fatty acid with double bond. Bent hydrocarbon chains.
Unsaturated fatty acids-
hydrogen at the same side of C=C bond
Cis form-
means the maximum number of hydrogen atoms are bonded to each carbon atom in a molecule of fat.
Saturated
Solid state at room temperature.
Saturated fatty acids
Found in animal fat such as milk, meat and butter others are vegetable oil and coconut oil.
Saturated fatty acids
High melting point and higher shelf-life.
Saturated fatty acids
Synthesized in the body.
Saturated fatty acids
Examples of Saturated fatty acids
Stearic Acid
Palmitic Acid
Capric Acid
Lauric Acid
Lower melting point thus liquid at room temperature.
Unsaturated fatty acids
Low shelf life. Not ideal for long storage.
Unsaturated fatty acids
Mostly plant sources like vegetable oil, sunflower oil, mustard oil, avocado oil.
Unsaturated fatty acids
Examples of Unsaturated fatty acids
Linoleic Acid
Oleic Acid
Types of unsaturated fatty acids
Monounsaturated
Polyunsaturated
1 double bond only in their structure.
Monounsaturated
contains more than 1 double bond in their structure
Polyunsaturated
Example of Polyunsaturated Fatty Acids
Omega 3 fatty acids
Omega 6 fatty acids
converting of unsaturated fatty acids to saturated fatty acids by addition of hydrogen hence straightening the hydrocarbon chain
Hydrogenation
Product of Hydrogenation of fatty acids
Trans fat
The worst type of fat because it raises the bad cholesterol since no enzyme from the body can metabolized it.
Trans fat
hydrogen on the opposite side of C=C. more linear compared to cis unsaturated fatty acids.
Trans fat
FATTY ACIDS according to number of carbon
Short Chain
Medium Chain
Long Chain
Prostaglandins
2-4 carbon atoms
6-10 carbons
12-16 carbons- found in diet
Prostaglandins - participate in inflammation and coagulation
Consist of 3 fatty acids attached to 1 glycerol by ester bonds.
Triglycerides (triacylglycerol)
Main storage form of lipids found in adipose tissue.
Triglycerides (triacylglycerol)
exist as oils (unsaturated)
Vegetable source
solid at room temperature (saturated)
Animal source
no charges
Neutral fats-
source of energy, structural membrane of the cells, insulation and shock absorber.
Triglycerides (triacylglycerol)
Similar with triglycerides structure except only 2 fatty acids are attached to the glycerol and attached phosphate group serves a head of the molecule.
Phospholipids
Most abundant lipids in the body.
Phospholipids
It forms a hydrophilic head and hydrophobic tail thereby attracting both water and fat.
Amphipathic-
Composed the phospholipid bilayer of the cell membrane.
Phospholipids
Types of phospholipid
Lecithin (phosphatidyl choline)
Sphingomyelin
Cephaline
important in the transport of fats in the plasma, brain and general cell structure
Lecithin (phosphatidyl choline)
found mostly in brain and nerve tissue.
Maintain cell membrane structure.
Sphingomyelin
comprises 10% of phospholipids.
phosphatidyl ethanolamine and phosphatidyl serine.
CEPHALINE
Consist of 4 rings (A,B,C and D), unsaturated steroid alcohol.
Cholesterols
Not a source of energy since it is not already catabolized by cells.
Cholesterols
Majority of cholesterol are synthesized by the
Liver
most abundant, consist of a cholesterol ring and fatty acids.
Cholesterol esters/esterified cholesterol-
Type of cholesterol with no fatty acids attached.
Free cholesterol/unesterified
Integral parts of the cell membrane (present in the lipid bilayer).
cholesterol
Begins at the small intestine through the action of enzymes and hormones.
Lipid metabolism
In the liver it forms into bile acids such as cholic acid and chenodeoxycholic acid that helps in the absorption of fats in the intestine ( fat emulsification).
cholesterol
Precursor for steroid hormones such as adrenal hormones, testosterone and progesterone
cholesterol
Precursor of vitamin D which facilitates the absorption of calcium (7-dehydroxycholesterol-Vit D3).
cholesterol
Lipid metabolism
Lipolysis
Lipogenesis
Ketogenesis
secreted by the intestine to stimulate lipases and bile.
Cholecystokinin(CCK)
emulsify fats. Secreted from the gall bladder.
Bile acids-
breaks down triglycerides to fatty acids then to monoglycerides.
Pancreatic lipase-
(breakdown of triglycerides into glycerol and fatty acids)
Lipolysis
(glucose conversion to fatty acids)
Lipogenesis
Occurs in the liver cells, adipose cells and lactating mammary glands.
Lipogenesis
(production of ketones)
Ketogenesis
primary ketone body in the blood.
β-hydroxybutyrate
serve as alternative source of energy of the brain.
Ketones
produced in times of low dietary intake of glucose such prolong fasting and starving (physiological).
Ketones
Excessive production of ketones are broken down into
CO2
Acetone