KIDNEY FAILURE AND KIDNEY FUNCTION TEST (TOPIC 3 NON-PROTEIN) Flashcards
Major Cause of CKD
T1 and T2 DM
Hypertension
Glomerulonephritis
Polycystic kidney disease
Certain medication
non enzymatic glycation which lead to glomerulosclerosis (scarring or hardening to glomeruli).
T1 and T2 DM
constant high pressure against the wall of renal artery causes to hardening (glomerulosclerosis)
Hypertension
infection or autoimmune in origin.
Glomerulonephritis
analgesic and aminoglycoside overdose.
Certain medication
detects proteinuria and blood cells.
Urinalysis-
staging of CKD. < 60 ml/min for 3 months.
Estimated GFR (eGFR)-
Urine albumin/creatinine ratio (ACR)- 24 H urine collection or random specimen.
ACR (mg/g) and Interpretation
A1
A2
A3
< 30
Normal to mildly increased
30-300 Moderately increase (microalbuminuria)
> 300 severely increase (macroalbuminuria)
URINE ACR formula
Urine albumin (g/dL)/urine creatinine (mg/dl)
Stage and eGFR (ml/min)
Normal kidney function. No signs and symptoms
1
> or = 90 ml/min
Stage and eGFR (ml/min)
Mildly reduce kidney function. No signs and symptoms
2
60-89 ml/min
Stage and eGFR (ml/min)
Mild to Moderate reduce kidney function. Signs and symptoms begin to show
3a
45-59 ml/min
Stage and eGFR (ml/min)
Moderate to severe reduce kidney function. Signs and symptoms are evident
3b
30-44 ml/min
Stage and eGFR (ml/min)
Severe kidney dysfunction. Recommended for dialysis
4
15-29 ml/min
Stage and eGFR (ml/min)
Kidney failure/End stage renal disease (ESRD). For dialysis or transplant
5
< 15 ml/min