Plasma Proteins And Enzymes In Diagnosis And Disease

Question 1

3 factors of protein levels?

Answer 1

Synthesis
Distribution
Removal

Question 2

Percentage of total hepatic production?

Answer 2

50%

Question 3

Types of albumin transport?

Answer 3

Fatty acids
Bilirubin
Drugs
Divalent ions
Hormones

Question 4

A1 antitypsin?

Answer 4

Mol. Weight 52 kDa
Synthesis in liver
Serine protease inhibitor
Many genetic variants

Question 5

a-Fetaprotein

Answer 5

Major plasma protein
Albumin like carrier protein
High levels can indicate heptocellular carcinoma

Question 6

a2-macroglobulin

Answer 6

High molecular weight protein (820kDa)

Inhibitor of proteases

Question 7

Caeruloplasmin?

Answer 7

Copper carrying protein

Function as ferroxidases and superoxide scavenger

Question 8

Plasma levels affected in:

Answer 8

Wilson’s disease:deficiency in copper transport

Menkes disease:copper absorption impaired

Question 9

Describe Haptoglobulin?

Answer 9

Tetrameric protein formed by two subunits

It binds free heamoglobulin released in hemalysis

Question 10

Describe Transferrin?

Answer 10

A B-globulin
30% saturated with iron
Feratin concentration opposite

Question 11

Describe C-reactive protein?

Answer 11

APP
part of immune system
Ideal marker for inflammation
High levels: risk of cardiovascular diseases

Question 12

5 enzymes in plasma?

Answer 12

Creatine kinase
Lactate dehydrogenase
Aminotransferase
Amylase
Alkaline phosphate

Question 13

Albumin description?

Answer 13

Abundant
69 kDa
Transport protein