Plasma membrane Flashcards
What is the charge of plasma membrane and who gives it?
Negative
Polar head are negative and fatty chain is uncharged
Three types of lipid bilayer
Phospholipid, glycolipid and sterols
What is lecithin?
Phosphotidylcholine
What are the negative glycerophospholipid?
Phosphotidylserine and phosphotidylinositol
Three types of glycolipid
Cerebroside, globoside and ganglioside
What are lipid rafts
Domain having cholesterol and sphingolipids
Two types of lipid rafts and their protein
Planar and caveolae.
Protein of planar is flotilin
Protein of caveolae is caveolin
Function of lipid rafts
Cholesterol trafficking, signal transduction, endocytosis.
Ionophores
They are small lipid molecules that are soluble in lipid and increases the permeability of specific inorganic solutes
Eg. of ionophores
Valinomycin, monensin and gramicidin A
What does Valinomycin, gramicidin and monensin does?
Valinomycin: transports k+ ions
Monensin : transport Na+ ions
Gramicidin A: transports water and univalent cations
How many aquaporins does human have? Which one is present on the epithelium of renal duct
10 isoforms and AQP2 is present on renal duct
Two hydrophobic domain of aquaporins consist of?
Asparagine, proline and alanine
N and C terminal of Aquaporins are in which side?
Cytosolic
Na+ K+ ATPase has how many subunits
Three a,b and r
Inhibitors of na-k ATPase
Oubain, digoxin, palytoxin and cardiotonic steroids
Hydropathy plot
The plot that determines the hydrophobic amino acid in a protein
P Type ATPase
Cation transporters that undergo reversible phosphorylation of a conserved aspartate residue
Eg. Of P type ATPase
Na-K ATPase, H-ATPase and Ca2+ ATPase
V Type ATPase
Transport protons.
Present in the vacuolar membrane, endosomal membrane and lysosomal membrane.
F Type ATPase
Transports only protons.
Doesn’t involve phosphorylation
Where is F Type ATPase found in eukaryotes.
Inner mitochondrial membrane
Where is F type ATPase found in plants
One in mitochondria and another in thylakoids
What does ABC transporters transport?
Ions, sugar, amino acids