Plasma membrane Flashcards

1
Q

What is the charge of plasma membrane and who gives it?

A

Negative
Polar head are negative and fatty chain is uncharged

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2
Q

Three types of lipid bilayer

A

Phospholipid, glycolipid and sterols

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3
Q

What is lecithin?

A

Phosphotidylcholine

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4
Q

What are the negative glycerophospholipid?

A

Phosphotidylserine and phosphotidylinositol

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5
Q

Three types of glycolipid

A

Cerebroside, globoside and ganglioside

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6
Q

What are lipid rafts

A

Domain having cholesterol and sphingolipids

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7
Q

Two types of lipid rafts and their protein

A

Planar and caveolae.
Protein of planar is flotilin
Protein of caveolae is caveolin

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8
Q

Function of lipid rafts

A

Cholesterol trafficking, signal transduction, endocytosis.

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9
Q

Ionophores

A

They are small lipid molecules that are soluble in lipid and increases the permeability of specific inorganic solutes

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10
Q

Eg. of ionophores

A

Valinomycin, monensin and gramicidin A

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11
Q

What does Valinomycin, gramicidin and monensin does?

A

Valinomycin: transports k+ ions
Monensin : transport Na+ ions
Gramicidin A: transports water and univalent cations

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12
Q

How many aquaporins does human have? Which one is present on the epithelium of renal duct

A

10 isoforms and AQP2 is present on renal duct

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13
Q

Two hydrophobic domain of aquaporins consist of?

A

Asparagine, proline and alanine

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14
Q

N and C terminal of Aquaporins are in which side?

A

Cytosolic

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15
Q

Na+ K+ ATPase has how many subunits

A

Three a,b and r

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16
Q

Inhibitors of na-k ATPase

A

Oubain, digoxin, palytoxin and cardiotonic steroids

17
Q

Hydropathy plot

A

The plot that determines the hydrophobic amino acid in a protein

18
Q

P Type ATPase

A

Cation transporters that undergo reversible phosphorylation of a conserved aspartate residue

19
Q

Eg. Of P type ATPase

A

Na-K ATPase, H-ATPase and Ca2+ ATPase

20
Q

V Type ATPase

A

Transport protons.
Present in the vacuolar membrane, endosomal membrane and lysosomal membrane.

21
Q

F Type ATPase

A

Transports only protons.
Doesn’t involve phosphorylation

22
Q

Where is F Type ATPase found in eukaryotes.

A

Inner mitochondrial membrane

23
Q

Where is F type ATPase found in plants

A

One in mitochondria and another in thylakoids

24
Q

What does ABC transporters transport?

A

Ions, sugar, amino acids

25
Where are ABC transporters found?
In plasma membrane, ER, mitochondria and lysosome.
26
Name the two domains of ABC transporter
Transmembrane domain and nucleotide binding domain
27
Give an example of ABC transporter and its function.
P Glycoprotein It's multidrug resistant. Especially in lung cancer cells.
28
CFTR
Cystic fibrosis transmembrane conductance regulator. A type of ABC transporter.
29
Where is CFTR found?
In lungs, gastrointestinal tract, liver, pancreas, sweat gland, and reproductive tract.
30
What does CFTR protein transport?
Chloride ions out of the cell.
31
What happens if the CFTR is defective?
Cystic fibrosis
32
Give an example of a secondary active transporter.
Na-glucose transporter and lactose permease (H - galactoside symporter)