Glycolysis And Pyruvate Oxidation Flashcards
Where does glycolysis take place
Cytosol and in some trypanosomes, in glycosome
Where does glycolysis take place
Cytosol and in some trypanosomes, in glycosome
Is glycolysis anaerobic?
No, works in both aerobic and anaerobic
Where is glucokinase formed
Hepatocytes and alpha cells of pancreas
Inhibitor of hexokinase
Glucose 6 phosphate
Inhibitor of phosphofructokinase and glyceraldehyde 3 phosphate dehydrogenase.
Phosphofructokinase - ATP, citrate, thioredoxin and glucagon (indirect)
Glyceraldehyde 3 P - Idoacetate
How does Idoacetate inhibit glyceraldehyde 3 phosphate?
By binding itself with -SH of cysteine residue of G3P dehydrogenase
How does Idoacetate inhibit glyceraldehyde 3 phosphate?
By binding itself with -SH of cysteine residue of G3P dehydrogenase
Inhibitor of enolase and pyruvate kinase
Enolase- Fluoride
Pyruvate kinase - Acetyl CoA
What does Rapoport Leubering Shunt do?
Decreases affinity with haemoglobin
Promotor of phosphofructokinase
Fructose 2 6 bisphosphate
Promotor of pyruvate kinase
Fructose 1 6 P
ATP formed in Glycolysis and in anaerobic condition
7 ATP and anaerobic 2 ATP
What is the major regulatory enzyme and rate limiting step
Phosphofructokinase
How does pyruvate enter mitochondria
By voltage dependant anion channel (porin)
And crosses inner mitochondria by pyruvate carrier.
