Physiology of the Auditory System Flashcards
Where is the basilar membrane displacement for high frequency noises?
at the base
where is the basilar membrane displacement for lower frequency sounds?
more apical
what is the structure of the membrane near the oval/round windows?
narrow and stiff
what is the structure of the membrane near the helicotrema?
it is wider and more flexible
how is the frequency of sound (pitch) coded?
by where along the basilar membrane there is greatest deflection
what type of cells are hair cells?
they are mechanoreceptors
what is on the apical end of hair cells?
stereocilia
what is the ion composition of endolymph?
it is high in K+ but low in Na+
where is endolymph found?
it fills the cochlear duct and the membranous labyrinth ; found in the scala media
what is endolymph produced by?
stria vascularis
what is the composition of perilymph?
it is potassium poor- low K+ but high Na+
where is perilymph found?
it is found in the scala vestibuli and scala tympani
what does the perilymph bathe?
the basal end of the cochlear hair cells
what does the endolymph bath?
the apical end of the hair cells
what happens when there is a pressure differential that will bend/ pivot the stereocilia in the direction of the longest stereocilia?
K+ ions will enter the cells and depolarize the cell
what are the specific Ca2+ ion channels that open due to a change in voltage?
TRPA1
deflection of stereocilia that causes depolarization will cause what?
release of the NT glutamate and a generation of action potentials in the 8th CN nerve fibers
what happens when there is deflection of stereocilia towards the shortest stereocilia?
hyperpolarization
what is the main role of the stria vascularis?
it maintains the electrochemical properties of the endolymph aka it keeps the scala media very highly concentrated with potassium
what forms the blood-labyrinth barrier?
the high endocochlear potential drives positively charged ions into the hair cell down its concentration gradient
what is a common source of ototoxic drug secretion into the cochlea?
the stria vascularis
what is the primary function of the inner hair cells?
these are the primary source of auditory information