Learning and Memory Flashcards
What are the two types of memory?
declarative and procedural memory
what are the anatomical substrates involved in procedural memory?
the cerebellum and the nucleus accumbens
where are habits stored?
in the nucleus accumbens
what are the two subdivisions of declarative memory?
episodic and semantic
what is episodic memory?
memory of events
what is semantic memory?
memory of words, language, and rules
how long is short term memory?
seconds to hours
how long is long term memory?
years
what is working memory?
recalling a fact for use in a test question; you’ve learned it, now youre retrieving it for use
the production of memory and learning requires the induction of what?
neuronal and synaptic plasticity
what are two forms of changes in synaptic functioning?
post-tetanic potentiation and long-term potentiation
what is plasticity?
alterations in the CNS based on use
what does post-tetanic stimulation result from?
there is a brief high frequency discharge of a presynaptic that produces an increase in NT release that lasts about 60 seconds
what is the mechanism of post-tetanic stimulation?
the high level of stimulation allowed more calcium to enter the terminal than can be “dealt” with–> the [Ca2+] concentration in the pre-synaptic terminal stays higher longer
what happens when there is more Ca2+ in the presynaptic terminal?
there is more Ca to bind to the docking proteins, which means that there will be more NT release
what is the result of post tetanic stimulation?
greater NT release and a greater probability of action potentials in the post-synaptic cell
what is long-term potentiation?
a series of changes in the pre and post synaptic neurons of a synapse
How long do long-term potentiation changes last?
more than 30 minutes
what does long term potentiation begin with?
more calcium in the post-synaptic terminal
what happens once calcium is inside the cell?
it binds with calmodulin
what happens once calcium binds with calmodulin?
there will be an increase in adenyl cyclase/ cAMP
what happens when there is an increase in cAMP?
the AMPA receptor will be phosphorylated
what happens when the AMPA receptor is phosphorylated?
we allow greater sodium influx to response to the same binding of the EAA–> we get more depolarization