Hypothalamic-Pituitary Relationships and Biofeedback Pt. II Flashcards
what does the adrenal medulla secrete?
catecholamines- epinephrine and norepinephrine
What are the zones of the adrenal cortex from outer to inner?
zona glomerulosa, zona fasciculata, and zona reticularis
what does the zona glomerulosa secrete?
mineralocortcicoids (aldosterone)
what does the zona fasciculata secrete?
glucocorticoids (cortisol)
what does the zona reticularis secrete?
androgens
what stimulates the release of CRH from the hypothalamus?
stress and the circadian rhythm
what is the effect of cortisol on the immune system?
immunosuppression
what is the effect of cortisol on the liver?
gluconeogenesis
what is the effect of cortisol on the muscles?
protein catabolism
what is the effect of cortisol on adipose tissue?
lipolysis
cortisol has negative feedback loops where?
directly inhibits the anterior pituitary from secreting more ACTH, directly inhibits the hypothalamus from secreting more CRH, and also suppresses infection and inflammation
do androgens secreted by the zona reticularis have any feedback loops on the anterior pituitary or hypothalamus
NO ONLY CORTISOL DOES
when are the secretory rates of cortisol the highest?
in the early morning
what is the main stimulus for aldosterone secretion by the zona glomerulosa?
decreased Na+ or increased K+ in the blood or decreased blood pressure
if you have low BP/ low Na+ in the blood and high K+ in the blood what is stimulated?
the kidneys are stimulated to release renin
what does renin cause?
the conversion of angiotensinogen to angiotensin 1 (which is inactive)
what catalyzes the angiotensin 1 into its active form and what is the active form?
ACE and the active form is angiotensin II
what does angiotensin II do?
it acts on the zona glomerulosa to secrete aldosterone
what are the effects of aldosterone?
it causes BP to increase, Na+ levels in the blood to increase–> water and Na+ reabsorption
What are the signs of cushing’s syndrome?
truncal obesity, moon face, buffalo hump, easy bruising, HTN, acne
cushing’s syndrome is a result of what?
chronic excess of glucocorticoids
what is the low-dose dexamethasone supression test used for?
to test for Cushing’s syndrome
what would be a normal test finding of a low dose dexamethasone test?
low cortisol levels