Physiology 4 - O2 transport Flashcards
how is O2 picked up in the lungs?
where is it transported to and for what use?
O2 is picked up in the lungs BY the BLOOD.
It is transported to the TISSUES for CELLULAR USE.
where is CO2 produced?
how is it transported?
where is it transported to and why?
CO2 is produced in the tissues.
transported by the blood.
transported to the lungs fo removal from the body.
what does Henry’s Law state?
the amount of a gas dissolved in a liquid (e.g. blood) at a constant temperature is
proportional to the partial pressure of the gas in equilibrium with the liquid.
for each mmHg of PaO2, how many ml of O2 are dissolved per litre of blood.
3ml of O2 per litre of blood at PO2 of 13.3kPa
if the cardiac output is at its normal of 5L/min, what would the oxygen delivery to tissues be?
15ml/min of oxygen delivery
what is the resting tissue oxygen consumption requirement at rest?
250ml/min is the requirement
give 2 ways in which O2 can be transported in the blood?
1) as free dissolved oxygen (PaO2) inn the blood plasma
2) as oxyhemoglobin in red blood cells (O2 bound to haemoglobin in red blood cells)
how many molecules of oxygen can each haemoglobin molecule carry?
each haemoglobin caries 4 OXYGEN MOLECULES.
is the binding of oxygen to haemoglobin reversible or irreversible?
REVERSIBLE
how many sub-units does haemoglobin have?
it contains 4 sub-units
what do each of these sub-units contain?
a NON-PROTEIN HAEM GROUP
what happens when oxygen binds to the haemoglobin sub-units?
it causes a CONFORMATIONAL CHANGE in the protein, altering the relationship with other protein sub-units & therefore the affinity of the haemoglobin molecule for oxygen
whats the name given to the process where the binding of oxygen alters the affinity of haemoglobin for oxygen?
co-operativity
when is haemoglobin considered fully saturated?
when haemoglobin is carrying its maximum O2 load
what is the primary factor which determines the percent saturation of haemoglobin with O2?
PO2
