Physio Flashcards
What percent of cell environment is made of H2O?
ICF?
ECF?
60%
40%
20%
PERCENTAGE
Plasma?
Interstitial?
5%
15%
ELECTROLYTES
Intracellular?
Extracellular?
Potassium Magnesium Phosphate Sulfate Proteins Organic Aniom
Sodium
Chloride
Bicarbonate
Calcium
Most abundant ECF cation?
Sodium
Most abundant ECF anion?
Chloride
Most abundant ICF cation?
Potassium
Most abundant ICF anion?
Organic Anion
RMP (mV)
Skeletal mm?
Cardiac?
Nerve?
Smooth mm?
- 90
- 85
- 70
- 40 to -60
CELL MEMBRANE
Aka?
Characteristics? (BAS)
Plasma membrane
Bilayer of lipids
Ampiphatic in nature
Semipermeable
Proteins in Cell Membrance?
mnemonics?
RICEMAP
Receptrors Ion channels Carriers Enzymes Markers Adhesions Pumps
Produces Lysosomes?
Produces Perixosomes?
Golgi apparatus
Smooth ER
Protein synthesis?
Lipid/Fat Synthesis?
Ribosomes
Smooth ER
Who has hydrolytic enzymes?
Who has oxidative enzymes?
Lysosomes
Peroxisomes
Capable of splitting a organic compound into 2 or more parts
Hydrolase (hydrolytic enzymes)
If GLYCOGEN is hydrolyzed?
If LIPIDS are hydrolyzed?
If PROTEINS are hydrolyzed?
Glucose
Fatty acids & glycerol
Amino acid
Capable of self replication?
Peroxisomes
Capable of combining of O2 c hydrogen ion to from hydrogen peroxide
Oxidase (oxidative enzymes)
Detoxifies free radicals?
Responsible for detoxification?
Peroxisomes
Smooth ER
What happens in PROPHASE?
??mnemonics??
DPP
Nucleus and nuclear envelope disappears
Centrioles moves to opposite poles
Chromosomes are paired
Downhill movement?
Uphill movement?
Diffusion/Passive transport
Active Transport
Spontaneous mvt of molecules from higher to lower areas of concentration (O2 & CO2)
Simple Diffusion
It uses carrier proteins (glucose & amino acids)
Facilitated Diffusion - Carrier Mediated
Uses chemicals (Ach - Ach & Ach binding receptors)
Facilitated Diffusion - Channel Mediated - Ligand Gated
Uses electrical current (action potential)
Ex: K+, Na+, Cl-, Ca++
Facilitated Diffusion - Channel Mediated - Voltage Gated
Factors that increases the rate of diffusion?
Higher temperature
Small molecular size
Higher partition coefficient (concentration difference)
OSMOSIS
Higher to lower?
Lower to higher?
Ex?
Water
Solutes
Renal, GIT
The mvt of sodium from OUTSIDE to INSIDE?
The mvt of sodium from INSIDE to OUTSIDE?
Facilitated Diffusion
Primary Active Transport
The mvt of sodium across the cell membrane is mainly by what cell transport?
Primary active transport
SECONDARY ACTIVE TRANSPORT
Na co-transport c?
Na counter transport c?
Glucose and amino acids
Ca & H ions
(nerve)
Cell Body aka?
Soma
Perikaryon
Site of AP initiation for both motor & sensory?
In sensory AP, if there is no initial segment, what’s the other answers?
Initial segment
1st node of ranvier / axon hillock
NERVE CONDUCTION VELOCITIES (m/s)
A alpha A beta A gamma A delta B C
120 70 40 15 14 2
(((Sing the song in Nerve physio)))
…
Who has the touch and pressure in nerve fibers?
But mainly in?
A beta
A alpha type 1B
A delta
A beta (also has pacinian corpuscles)
Fast channels?
Slow channels?
Na channels
K channels
RMP
They return the Na and K ions to their og location — How many Na and K?
(???mnemonics???)
TriNaOut, 2Kin
3 Na out
2 K in
What type of mm that has NO TROPONIN?
Smooth mm
COVERINGS
Epimysium?
Perimysium?
Endomysium?
Skeletal mm
Mm fascicle/bundle
Mm fiber
Functional unit of a muscle fiber
Sarcomere
WHAT HAPPENS DURING MUSCLE CONTRACTION Actin H-zone I-band A-band (length of myosin)
Approximate
(Himala) Disappears
(Ikli) Narrows
(Ala) Nothing
Cell membrane of mm fiber
Sarcolemma
Cytoplasm of mm fiber
Sarcoplasm
Where can you see the Sarcotubular System?
Between A and I band
What composes the Sarcotubular System?
T-TRIAD
2 Sarcoplasmic reticulum
1 T-tubule (transverse tubule)
What made up of Actin?
2 F-actin (filamentous)
What made of F actin?
2 G-actin (globular)
TROPONIN
Troponin I?
Troponin C?
Troponin T?
Covers the binding sites
Calcium
Forms a complex called troponin-tropomyosin complex
ACH RECEPTORS
Skeletal mm?
Smooth mm?
Nicotinic
Muscarinic
At what length can a muscle generates the highest tension?
Resting length / Optimal position
RBC
Male?
Female?
- 2-6.5 millions/mm3
4. 5-5.5 millions/mm3
HGB
Male?
Female?
14-18 g/dL (16)
12-16 g/dL (14)
HEMATOCRIT
Male?
Female?
42-52%
37-47%
ESR
Male?
Female?
<15mm/hr
<25 mm/hr
Normal value of WBC
5,000-10,000/mm3
Normal value PLATELET
150,000-400,000/mm3
Bleeding time
1-6mins
Clotting time
6-10 mins
BLOOD VALUES TAHT ARE C/I TO EXERCISE? WBC? Hematocrit? Hemoglobin? Platelet?
Light exercise in platelet?
<5,000/mm3
<27%
<8g/dL
<20,000/mm3
20,000-50,000/mm3
BLOOD
Total % of body weight?
Thicker than h2o?
Average blood volume?
Female?
Male?
Average?
8%
5x thicker
4-6L
4-5L
5-6L
5L
FUNCTIONS OF BLOOD
???mnemonics???
BLOOD CPH
Balances acid and base Levels temperature Osmosis O2 transport Delivers nutrients Clotting formation Protection Hormonal transport
PERCENTAGE of:
Formed Elements?
Plasma?
FORMED ELEMENTS
- RBC?
- WBC?
- Platelets?
PLASMA
- Water?
- Plasma proteins?
- Other substances?
45%
55%
FORMED ELEMENTS
- 95%
- 4%
- 1%
PLASMA
- 91%
- 7%
- 2%
PLASMA PROTEINS
Mnemonics?
AGF
Albumin
Globulin
Fibrinogen
PERCENTAGE OF PLASMA PROTEINS
Albumin?
Globulin?
Fibrinogen?
58%
38%
4%
Most abundant plasma protein?
*Most abundant protein in the body?
Albumin
Collagen
Least abundant plasma protein?
Fibrinogen
Plasma protein that is responsible for immunity?
Globulin
OTHER SUBSTANCES (Plasma component in blood) Mnemonics?
WING
Waste products
Ions
Nutrients
Gases
RBC Aka? Function? Lifespan? Graveyard?
Erythrocytes
O2 transport
120 days
Spleen
IRON
Protein escort in bloodstream c iron?
Protein escort inside the cell c iron?
Transferin
Ferritin
All formed elements are derived from a single population of cells called??
PHSC (Pluripotential hematopoietic stem cell)
aka
Hemocytoblast
RBC FORMATION
Mnemonics?
Stages?
PoBRE
Proerythroblast aka Pronormoblast
Basophil Erythroblast
Reticulocyte
Erythrocyte
1st generation of cell that it starts to acquire Hgb?
Basophil Erythroblast
Immature RBC / Young RBC
Ejection of nucleus
Reticulocyte
Stimulus that can do Erythropoiesis?
Erythropoietin
ERYTHROPOIESIS
Kidney?
Liver?
90%
10%
FACTORS THAT INCREASE RBC FORMATION
Mnemonics?
BATCH
Bone marrow disease Altitude is high Tissue hypoxia Circulatory disease Hemorrhage
IMPORTANT VITAMINS FOR RBC FORMATION?
Vit B12
Folic acid
Iron
OTHER NAMES:
Vit B12
Folic Acid
Cyanocobalamin
Pteroylglutamic acid
Which vitamins that is important for DNA SYNTHESIS?
Which vitamins that is important for HEMOGLOBIN SYNTHESIS?
Vit B12, Folic Acid
Iron
Primary Polycythemia aka?
Polycythemia Vera
Complete depletion of iron
Plummer Vinson Syndrome
Plummer Vinson Syndrome
TRIAD? Mnemonics??
DIE
Dysphagia
Iron deficiency anemia
(+) esophageal web
2 types of MEGALOBLASTIC ANEMIA
Pernicious Anemia
Folic Acid Anemia
Increase destruction of RBC
Hemolytic Anemia
Hemoglobin S
Sickle cell anemia
(+) pain crisis
Sickle cell anemia
Red cells are very small & spherical and cannot withstand compression forces
Hereditary Spherocytes
Erythroblastosis Fetalis aka?
HDN
Hereditary Disease of Newborn
Cerebral Palsy assoc c Erythroblastosis Fetalis
Athetoid CP
3 Types of Hemolytic Anemia
Sickle cell anemia
Hereditary Spherocytes
Erythroblastosis Fetalis
WBC LIFESPANS
Granulocytes
Blood?
Tissues?
Agranulocytes
Blood?
Tissues?
4-8 hrs
4-5 days
10-20 days
Approx 3 months
Types of Granulocytes WBC
Mnemonics?
BEN-G
Basophil
Eosinophils
Neutrophils
Most abundant WBC?
2nd most abundant WBC?
Least abundant WBC?
Neutrophils
Lymphocytes
Basophils
Smallest WBC
Lymphocytes
Largest WBC
Monocytes
WBC responsible for:
Bacterial infection?
Parasitic infection?
Viral infection?
Neutrophils
Eosinophils
Lymphocytes
Primary cells in Innate Immunity
Basophils Eosinophils Neutrophils Monocytes Mast cells Macrophage
Releases antibodies
B cells
Releases cytokines
T cells
Site of maturation of T cell
Thymus
Primary action is phagocytosis and inflammatory response
Innate immunity
Primary action is protection against EXTRACELLULAR ANTIGENS
Adaptive immunity - Humoral mediated
Primary action is protection against INTRACELLULAR ANTIGENS
Adaptive immunity - Cellular mediated
1st line of defense?
Mnemonics for types of 1st line of defense?
Tissue macrophages
KALBS Kuppffer cells (liver) Alveolar macrophages (lungs) Lymphoid macrophages (lymph nodes) (Brain) Microglia (Skin) Histiocytes
2nd line of defense?
Neutrophils