Photodermatology Flashcards
1
Q
What are chromophores?
A
- Chemicals which absorb radiation
2
Q
Accumulation of chromophores is dependant on what?
A
- Water and fat solubility
3
Q
Porphyrias are characterised as what?
A
- Blistering of skin
- metabolic conditions
- inherited or acquired
- porphyrin pathway involved in haem synthesis
4
Q
The porphyrin pathway is involved in what?
A
- Haem synthesis
5
Q
What is the most common porphyria?
A
- Porphria cutanea tarda (PCT)
6
Q
What enzyme is reduced in PCT?
A
- Uroporphyrinogen decarboxylase
7
Q
What is the clinical presentation of PCT?
A
- Skin blisters
- fragility
- hyperpigmentation
8
Q
What investigation is done into PCT?
A
- Wood’s lamp
9
Q
What may be some underlying causes of PCT?
A
- Alcohol
- viral hepatitis
- oestrogens
- haemochromatosis
10
Q
What enzyme is reduced in Erythropoietic protoporrphyria?
A
- ferrocherlastase enzyme
11
Q
In EPP what substance builds up that then causes photosensitivity?
A
- protoporhyrin
12
Q
What should be checked every 6 months in EPP?
A
- LFTs
- check for EPP induced liver disease
13
Q
What are some photoprotection measures?
A
- behavioural
- clothing
- environmental (shade)
- topical sunscrean
14
Q
Acute intermittent porphyria doesnt’ usually affect the skin?
TRUE OR FALSE?
A
- TRUE
