Pharmacology and therapeutics Flashcards
Transdermal means?
- across the skin
Subcutaneous means?
- injected into the body, bypasses the skin
What is another name given to the keratin layer of the skin?
- Stratum corneum
What does the stratum corenum contain?
- corneocytes (differentiated keratinocytes)
In the brick and mortar model what does the mortar represent?
- multiple lamellar structures of intracellular lipids, cholestrol and free fatty acids
Drug delivery into and across the startum corneum is a ___ process
- passive process
- diffusion
Intercellular absorption of a drug is hydro__
- hyprohophic
Transcellular absorption of a drug is hydro____
- hydrophillic
What factors influence absorption of a topical drug?
- permeability coefficent
- concentration of a drug
- length of diffusion pathway
What are roles of vehicles?
- contain other properties to allow for drug absorption
- factors affecting vehicles: concentration of drug, movement of drug from vehicle into the keratin layer
Which drug has a higher water content?
Ointments vs lotions?
- lotions
Which drug has a higher water content?
Ointements vs gels?
- Oitments
Drugs which are lipophillic in vehicles that are lipophillic means what?
- soluble in both the vehicle and the skin
Drugs which are lipophillic in hydrophilic bases means what?
- the drug is more soluble in the skin
Hydrophillic drug in a lipophillic base has what solubility?
- limited solubility
