Immunology

Question 1

What is the function of keratinocytes in the epidermis?

Answer 1

• structural and function cells of the epidermis
• sense pathogens
• produce antimicrobial peptides (AMPs)
• produce cytokines

Question 2

What are langerhan cells?

Answer 2

• type of dendritic cells
• intersperse with keratinocytes
• antigen presenting

Question 3

What T cell is mainly found in the epidermis?

Answer 3

• CD8+T cells

Question 4

What T cell is associated with psoriasis?

Answer 4

• TH1

Question 5

What T cell is associated with atopic dermatitis?

Answer 5

• TH2

Question 6

What T cell is associated with psoriasis and atopic dermatitis?

Answer 6

• TH17

Question 7

What is a class 1 MHC molecule?

Answer 7

• found on almost all cells

- Cytotoxic presentation (CD8)

Question 8

What is a class 2 MHC molecule

Answer 8

• found on antigen presenting cells

- CD4

Question 9

What are the immunological features of atopic eczema?

Answer 9

• defective skin barrier
• allows access to allergen
• promotes colonisation

Question 10

What is the immune features of the epidermis?

Answer 10

• Keratinocytes
• Langerhan cells
• T cells

Question 11

What is the immune features of the dermis?

Answer 11

• Dendritic cells
• Macrophages
• Mast cells
• Neutrophils

Question 12

What are the two types of dendritic cells found in the dermis?

Answer 12

• Dermal DC

- Plasmacytoid DC

Question 13

What T cells are found in the dermis?

Answer 13

• CD4+ T cells

- CD8+ T cells

Question 14

What cell produces AMPs (antimicrobrial peptides)

Answer 14

• keratinocytes

- epidermis

Question 15

Type I hypersensitivity reaction is Ig_ mediated?

Answer 15

• IgE

Question 16

Type II and III hypersensitivity reaction is Ig_ and Ig_ mediated

Answer 16

• IgG

- IgM

Question 17

Autoimmunity is?

Answer 17

• Reaction to the host

- Can result in chronic inflammation

Question 18

Immunodeficiency is?

Answer 18

• Infection not controlled

Question 19

Hypersensitivity is?

Answer 19

• Overeaction to antigen

- immune response that causes collateral damage to self

Question 20

The keratin layer is formed of what?

Answer 20

• Terminal differentiation of keratinocytes to corneocytes

Question 21

Type I hypersensitivity reaction is what mediated?

Answer 21

• IgE

Question 22

Type II hypersensitivity reaction is what mediated?

Answer 22

• IgG

- IgM

Question 23

Type III hypersensitivity reaction is what mediated?

Answer 23

• Complex mediated

Question 24

Type IV hypersensitivity reaction is what mediated?

Answer 24

• Cell

- T-cell

Question 25

What is the definition of allergy?

Answer 25

• Hypersensitivity disorder of the immune system

Question 26

What is the presentation of a type I hypersensitivity reaction?

Answer 26

• Urticaria
• angioedema
• wheeze
• anaphylaxis

Question 27

What investigations can be performed for a type I hypersensitivity reaction?

Answer 27

• Skin prick
• history most important
• challange testing

Question 28

Management of allergy?

Answer 28

• Allergen avoidance
• anti-histamines
• Corticosteriods
• adrenaline (anaplylaxis)

Question 29

What is the adrenaline dosage for children in anaphylaxis?

Answer 29

• 150ug

Question 30

What is the adrenaline dosage for adults in anaphylaxis?

Answer 30

• 300ug

Question 31

What is different between a contact irrant dermatitis and a type I hypersensitivity reaction?

Answer 31

• Contact dermatitis doesnt require previous exposure to irritant

Question 32

Contact dermatitis is what type of hypersensitivity?

Answer 32

• Type IV