Phosphoglycerate Mutase: Step 7 of Glycolysis

Question 1

What reaction does PGM (phosphoglycerate mutase) catalyze?

Answer 1

Conversion of 3-phosphoglycerate (3PG) to 2-phospoglycerate (2PG).

Question 2

What does PGM stand for?

Answer 2

Phosphoglycerate mutase

Question 3

What are the two steps of phosphoglycerate mutases catalyzation of the reaction of 3PG to 2PG?

Answer 3

1) Enzymes phosphoryl group transferred to 3PG to make 2, 3 BPG
2) 2, 3 BPG decomposes to leave a phosphoryl group on the enzyme and 2-phosphoglycerate as the product.

Question 4

Occasionally 2,3-BPG breaks away; what is this 2,3-BPG used for?

Answer 4

1) Control of hemoglobin (decreases Hb’s affinity for O2)

2) Used to jumpstart histidine if it has no phosphate group