Phosphofructokinase: Step 3 of Glycolysis Flashcards

1
Q

Why reaction is catalyzed by phosphofructokinase?

A

The phosphorylation of fructose 6-kinase to form fructose-1, 6-bisphosphate.

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2
Q

Why is fructose-1,6-bisphosphate a “bis” rather than “bi” product?

A

Because the two phosphates are not directly attached to each other.

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3
Q

How is phosphofructokinase (PFK) similar to hexokinase?

A

It requires ATP and Mg2+ to phosphorylate its substrate.

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4
Q

What is the key regulatory enzyme for glycolysis?

A

Phosphofructokinase (PFK)

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5
Q

True or false: The reaction from fructose-6-phosphate (F6P) to fructose-1,6-bisphosphate (FBP) is reversible?

A

False

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6
Q

What molecule allosterically enhances the activity of PFK?

A

AMP

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7
Q

What allosterically inhibits PFK?

A

ATP and citrate

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8
Q

What enzyme catalyzes the reaction from F6P to FBP?

A

Phosphofructokinase

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9
Q

Why does AMP enhance the activity of PFK?

A

ATP breaks down into ADP and AMP, so high concentrations of AMP signal that ATP concentration is low.

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