Pharmacology II Flashcards
Drugs with slight anticholinergic effects
DiTriBeAM
diophenhydramine Tricyclic antidepressants Benzodiazepines Antipsychotics Meperidine
Gold standard of narcotics
Morphine
Narcotics aka
Opioids
Opiates
Opium
Morphine came from what plant
Poppy plant
Papaver somniferum
Opioid receptors (4)
Limbic system
Area postrema
Solitary nuclei
Substansia gelatinosa of rolando
LASS
Most common side effect of narcotics
Nausea
Gate in gate control theory
Substansia gelatinosa of rolando
Most accepted theory for pain
Gate control theory
Opioid receptor responsible for nausea and vomiting
Area postrema
Anti tussive drug
Dextromethorpan (rubitussin)
Opioid receptor responsible for gag reflex cough reflex baroreceptor reflex chemoreceptor and gastric motility
Solitary nuclei
Endogenous opioids produced by body (2)
Enhephalins
Endorphins
Combination of Diphenoxylate and Atropine
Lomotic
Laxative drug
Bisacodyl
Drug for expectorant
Guaifenesin
Narcotic agents block pain in PNS T or F
False
Morphine triad
Miosis
Respi depression
Coma
Components or drugs of neuroleptic analgesia
Neuroleptic agents or antipsychotics
Narcotics
Nitrous oxide
3N
example of neuroleptic drug
butyrophenones
Drug that causes dissociative anesth
Ketamine
*drug that places px in trans like state
Ketamine
Contraindicated drugs to glaucoma
Diazepam
Anticholinergic drugs!!!
(ditribeam)
Other name of heroin
Diacetylmorphine
Other name for acetaminophen
APAP
N-acetyl paraminophenol
Oxycodone + acetaminophen = ______
Tylox
Drug for orofacial pain
Codeine
Real anticholinergics ***
Belladona alkaloids
Atropine
Scopolamine
Dse Associated with px taking meth
Meth mouth
drug that shouldnt be combined with MAO inhibitors
MEPERIDINE
SSRI
Ephedrine
Epineph
Street name for heroin
Horse
Big H
Brown sugar
Street name for cocaine
Coke
Candy
Street name for methamphetamine HCL
Crystals
Meth
Shabu
Poormanโs cocaine
Street name for marijuana
MJ
Weed
Blunt
Came from cannabis sativa
Oxycodone drug
Percocet
Route of administration
Codeine, oxycodone, methadone
Oral
Morphine and meperidine route of administration
Parenteral (IV)
Narcotic antagonists (2)
Naloxone
Naltrexone
Drugs with respiratory depression and dependence (4)
SNAB
Sedative hypnotics
Narcotics
Alcohol
Benzodiazepines
Impaired control over taking the drug
Psychic dependence
Continued administration of the drug is required to prevent unpleasant withdrawal syndrome
Physical dependence
Inhalation drugs
Halothane
Desflurane
Blocks cox in CNS
Acetaminophen
Acetaminophen is ____ acting
Centrally acting non narcotic analgesic
Hepatotoxic drugs
Acetaminophen
Rifampicin
Tetracyclines
Narcotics metabolized to a CNS stimulant
Meperidine (Demerol) - NORmep
Propoxyphene (Darvon)
Drugs with different classification from books opioids or non opioids
Tramadol
Propoxyphene (Darvon)
Petazocaine (Talwin)
Non scheduled narcotics
Tramadol
Drugs with neuroleptic anesthesia (3)
Narcotic
Butyrophenones (anti psychotic)
Nitrous oxide
Receptor of leukotrienes
Leukotriene receptor
If leukotrienes binds to receptor it will result to ______
Bronchoconstriction - reason for asthma
Prevent bronchoconstriction of leukotrienes
Leukotriene receptor blocker
Leukotriene receptor blocker drug
Montelukast
Both CNS and PNS have cyclooxygenase T or F
True
If arachidonic acid went to CNS there would be production of ____
CoX2 - produces prostaglandins
Effect of prostaglandin to CNS
Fever
Pain
Cox 1 in PNS produces
Thromboxane A2 - formed by platelets
Prostaglandins
Prostaglandin in cox 1 PNS effect
Inc renal blood flow
Cox 2 in PNS produces
Prostaglandins
Prostacyclin
Effects of prostaglandin in cox 2 PNS
Pain
Vasodilation
Effect of prostacyclin in cox 2 PNS
Vasodilation
3 end product of cyclooxygenase
Prostaglandin
Prostacyclin
Thromboxane a2
Non narcotics takes place to PNS except what drug
Acetaminophen
Drug that inhibit both COX 1 and 2 and is mainly peripherally acting
nsaids
Uses of non narcotic agents (3)
Anti pyretic
Analgesic
No inflam effect
Aspirin irreversibly block ____
Cox 1 in platelets
Aspirin and salicylates PNS or CNS
PNS
Prior to surgery, when should px stop taking aspirin
7 days
Reyeโs syndrome
Child
Viral
Aspirin
Drug used to treat salicylism
Sodium bicarbonate
What parent drug is converted to acetaminophen
Phenacetin
Narcotic agents when excessive dose can lead to narcotic like adverse effects (2)
Pentazocaine
Propoxyphene
Aspirin + NSAIDS can enhance (2)
Warfarin (Coumadin)
Coumarin
NSAIDS drug uses (3)
Anti inflam
Analgesics
Mild anti pyretic
Which of the ffg drug should not be given if px will undergo surgery
NSAIDS (aspirin) PART OF NSAIDS PADIN
NSAID that selectively blocks COX 2
Cox 2 inhibitor
Only nsaid with no side effects
Cox 2 inhibitors
Type of non narcotic without anti inflam effect
Acetaminophen
Classification of aspirin (3)
Non narcotic
NSAID
salicylates
Drg uses of aspirin (4)
Anti pyretic
Analgesics
Mild anti inflam
Blood thinner
Overdose of aspirin
Salicylism
Cox 2 inhibitor drugs
Celecoxib
Etoricoxib
Valdecoxib
Ideal days for taking cox 2 inhibitor
7days
Cox 2 inhibitors reduces pain, fever, and inflammation without having GI problems T or F
True
Steroidal drugs suffix
- sone
- lone
Corticosteroids rx
Bilateral mandibular radiolucencies
Steroidal drugs inhibits ____ resulting to dec arachidonic acid
Phospholipase a2
Steroidal drug uses
Anti inflam Immunosuppressants Prevents graft rejection Prevents prosthetic rejection Tx for addison dse
*before surgical extraction, what will do if px is under long term steroidal therapy
Increase dose or double the dose
Antipsychotic drugs aka (3)
Major tranquilizers
Neuroleptic agents
Hallucinogens
Dse with excessive dopamine levels
Schizophrenia
Dse with dec dopamine
Parkinsonโs dse
Adverse effect of first gen antipsychotics
Extra pyramidal syndrome (tardive dyskinesia)
First gen antipsychotic drugs (3)
Phenothiazines - chlorpromazine
Butyrophenones - droperidol
Thioxanthenes
Second gen antipsychotic drug
Clozapine
Second gen has (4) receptor antagonist in limbic system
D1
D2
D4
D5
Bipolar disorder aka
Manic depression syndrome
DOC for manic depressive syndrome
Lithium ion
Antidepressant drug given to bipolar px
Tricyclic antidepressants
Most common TCA
Amitriptyline (si ami laging pinagttripan)
Drug given to px with tourettes
Antipsychotic drugs
Pharma effects of antipsychotics (5)
Reduction in psychosis Emotion quieting Dec convulsion Sedation Anticholinergic effect
Adverse effect of antipsych drugs
Tardive dyskinesia
Parkinsonism
Akathisia
Antipsychotic mainly d2 receptor antagonist
First gen antipsychotics
Antipsychotic drug with antihypertensive properties
Reserpine
Drugs for parkinsons dse (4)
L-dopa
Stimulants
MAO inhibitors
Anticholinergic drugs
Neuroleptic analgesia
A. Narcotics
B. Butyrophenones
C. N2O2
C
Which of the ffg drugs can be used to treat parkinsonism like symptoms
A. Anticholinergic
B. Narcotics
C. Antidepressants
A.