Pharmacology - Antidepressants - Oliver Brown Flashcards
T/F: Most antidepressant drugs block the reuptake of both NE and 5HT to varying degrees.
True
Give the class: Tranylcypromine
MAOI
Give the class: Fluoxetine
SSRI
Give the class: Citalopram
SSRI
Give the class: Duloxetine
SNRI
serotonin-norepi reuptake inhibitor
Give the class: Venlafaxine
SNRI
Give the mechanism:
Tranylcypromine
Phenelzine
Irreversibly inhibit both MAO-A and MAO-B
MAOI
Give the side effects: Tranylcypromine
Hypertensive crisis (with tyramine-rich foods); serotonin syndrome (MAOI + SSRI)
Anticholinergic, orthostatic hypotension, sexual dysfunction, weight gain, sedation, insomnia, dizziness
What is Tranylcypromine used for:
Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
Give the mechanism: Fluoxetine Sertraline Citalopram Escitalopram Paroxetine
Inhibit reuptake of 5-HT (and NE to lesser extent)
SSRI
Give the indication: Fluoxetine Sertraline Citalopram Escitalopram Paroxetine
Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism; pre-menstrual dystrophic disorder
Give the side effects: Fluoxetine Sertraline Citalopram Escitalopram Paroxetine
Serotonin syndrom (with MAOIs)
Fewer than tricyclics; mostly nausea, decreased sexual function
What is unique about Fluoxetine and Paroxetine as SSRIs?
They are Potent P450 inhibitors; form active metabolite (norfluoxetine)
Specifically CYP2D, CYP2C, CYP2A
Give the class: Venlafaxine (Effexor)
SNRI
Give the mechanism:
Duloxetine (Cymbalta)
Venlafaxine (Effexor)
Inhibits reuptake of 5-HT and NE
Give the indication:
Duloxetine (Cymbalta)
Venlafaxine (Effexor)
Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
Give the class: Buproprion
Atypical antidepressant
Give the class: Mirtazapine
Atypical antidepressant