Behavioral Science - eating disorders Flashcards
T/F obesity is a diagnosable condition marked by being more than 20% over ideal weight with BMI > 30
True
What two receptor mutations are associated with obesity?
Leptin receptor mutation
Melanocortin 4 receptor mutation
Blocking which histamine receptor can cause weight gain?
Blocking histamine 1 receptor - makes you tired and groggy but also turns off satiety center (fat because you don’t feel full and keep eating)
Blockade of muscarinic receptors (Achm) results in weight gain or weight loss?
Weight gain
Blockade of 5HT2c receptors cause weight gain or weight loss?
Blockade or serotonin 2c receptor raises NE and DA in cortex (good for depression) but also removes inhibitory control on fat cell growth causing weight gain
Increased prolactin levels correspond to weight gain - blockade of which receptors can indirectly trigger this?
D2 receptor blockade
What are the two types of drugs that contribute the most to “iatrogenic” obesity?
Anti-psychotics and anti-depressants
What are 3 lifestyle factors that contribute to obesity?
sedentary lifestyle
dependence on automobiles
Large portion sizes with high fat/carb content
When would you consider bariatric surgery or gastric banding for treatment of obesity?
When lifestyle modification therapy (e.g. attempts to lose weight with diet, exercise) fails
Why are amphetamines an effective weight loss medications?
decrease appetite
T/F research data has shown that exercise rather than diet is the better target for obesity treatments
False - exercise alone isn’t enough to curb obesity - diet has the largest impact on weight gain/loss
Pharmacological treatments can be very effective for weight loss. Why are they not considered a long term solution?
Rebound appetite increase after medication is stopped. Long term solutions are lifestyle and behavioral modifications (portion control etc.)
What is orlistat?
What are major side effects?
weight loss medication that inhibits gastric lipase so fats don’t get absorbed/metabolized
profuse diarrhea and fecal accidents
What are topiramate and zonisamide?
anti-convulsant medications used for weight loss
How do the anti-convulsant medications (topiramate and zonisamide) facilitate weight loss?
lower gluconeogenisis and improve carb metabolism (results in less conversion to fat)
What is phentermine?
psychostimulant that is used primarily to cause appetite suppression and weight loss
topiramate/phentermine are used in conjunction for weight loss medications due to which properties?
improved carb metabolism and appetite suppression
Why is naltrexone effective for weight loss?
opiate receptor blocker prevents reward sensation from after eating (interrupts positive re-enforcement)
Why is bupropion effective for weight loss?
appetite suppressant
What is lorcaserin?
5HT2c receptor agonist - used as weight loss medication because it increases metabolism (by inhibiting adipocyte growth)
What are the 3 required diagnostic criteria for DSM-5 diagnosis of anorexia nervosa?
1) Persistent restriction of energy intake leading to low body weight
2) Intense fear of gaining weight or of becoming fat
3) Body image disturbance (dysmorphism)
T/F Missed menstrual cycles (x3) and refusal to maintain 85% typical weight can substitute for other diagnostic criteria for anorexia nervosa.
False - these criteria were from DSM4; no longer in DSM 5
What are the two subtypes of anorexia nervosa?
Restricting type = does not eat, does not purge
Binge/Purge Type=does binge or purge
How is anorexia nervosa scaled for severity?
Severity based upon BMI and classified as mild, moderate, severe, or extreme
What constitutes mild, moderate, severe, extreme anorexia nervosa?
Severity based upon BMI (so depends on weight and height)
Mild >17 kg/m2
Mod 16-16.99
Severe 15-15.99
Extreme