Pharmacology and Clinical chemistry

Question 1

What biochemistry does Pagets disease of the bone present with?

Answer 1

Normal electrolytes but markedly raised ALP.

Mixed osteolytic, osteoblastic and sclerotic bony appearance is also characteristic of Paget’s disease

Question 2

Which clinical sign is associated with hypocalcaemia?

Answer 2

Trosseau’s sign

Inflate BP cuff and pts hand and forearm spasms

Question 3

What is the common side effect experienced with amoxicillin?

Answer 3

Rash with infectious mononucleosis

Question 4

What is the common side effect experienced with co-amoxiclav?

Answer 4

Cholestasis

Question 5

What is the common side effect experienced with flucloxacillin?

Answer 5

Cholestasis (usually weeks after use)

Question 6

What is the common side effect experienced with erythromycin?

Answer 6

GI upset and prolonged QT

Question 7

What is the common side effect experienced with ciprofloxacin?

Answer 7

Lowers seixure threshold and tendonitis

Question 8

What is the common side effect experienced with metronidazole?

Answer 8

Reaction following alcohol ingestion

Question 9

What is the common side effect experienced with doxycycline?

Answer 9

Photosensitivity

Question 10

What is the common side effect experienced with trimethoprim?

Answer 10

Rashes, including photosensitivity, pruritis and suppression of haematopoesis