Pharmacology

Question 1

Airway smooth muscle preganglionic neurons are from

Answer 1

the vagus nerve (CNX)

Question 2

Parasymp Postganglionic cell body receptors

Answer 2

M3 (bronchi and bronchioles SM and goblet cells) ; nitrergic (bronchial SM relax due to VIP and NO)

Question 3

sympathetic NS affects airway through

Answer 3

adrenaline and noradrenaline (produced in chrommafin cells of adrenal medulla)

Question 4

adrenaline affect on airway

Answer 4

β2 receptor on epithelial, goblet and airway SM - decrease mucus, relaxation, increased clearance

Question 5

noradrenaline affect on airway

Answer 5

α1 receptor on vascular SM => contract

Question 6

contraction in SM mainly caused by __ stimulating ___ to degrade ___ to __ to release ___ from

Answer 6

G receptor stimulates Phospholipase C to degrade PIP2 to IP3 to release Ca2+ from SR

Question 7

2ndry method of contraction of SM

Answer 7

Ca2+ enters cell and activates ryanodine (Ca activated Ca) receptor to release SR Ca2+

Question 8

How cytoplasmic Ca2+ caused SM contraction

Answer 8

binds to calmodium ->activate MLCK -> +ATP phosphorylates myosin crossbridge and binds with actin = slide

Question 9

dephosproylation of MLC by ____ causes ___

Answer 9

myosin phosphatase ; SM relaxation

Question 10

How adrenaline causes relaxation of bronchial SM

Answer 10

to β2 ->Gs -> adenylyl cyclase -> cAMP -> protein kinase A -> inhibits MLCK and stimulates myosin phosphatase