Pharmacokinetics Assessment Flashcards
A pt. has issues with his renal function which may affects his capacity to to excrete his medications. You must assess the patient more frequently for what development?
Increased risk for drug toxicity.
4 Phases of pharmacokinetics?
Absorption, distribution, metabolism, excretion
Nurse is teaching a client the importance of taking the medication as prescribed. Client teaching is guided by the nurse’s knowledge of which principles of pharmacokinetics?
- A drug may be exposed to several physiological processes while en route to target cells.
- Liver enzymes may chemically change the drug.
- Excretion organs such as kidneys and intestines must be healthy enough to eliminate the drug.
- Many process to which drugs are exposed are destructive, thereby helping facilitate the drug’s movement throughout the body.
The nurse has just administered a client’s morning dose of medications following a high-fat breakfast. How will the absorption of the medication be affected?
It will be slowed.
A client is receiving antibiotic treatment for a wound abscess. What does the nurse recognize that drug distribution to this area requires, in order to be effective?
adequate blood perfusion to the area.
A client is admitted to the burn unit with 75% body surface area burns. Which orders would be appropriate for this client to control pain?
- Morphine 10 mg IV every 2-4 hrs as needed for pain.
- Morphine 10 mg sublingual every 2-4 hrs as needed for pain.
When administering a high protein-bound drug to a client, what can the nurse expect?
Duration of action will be prolonged.
A client has been started on diltiazem (Cardizem), a susbstrate of the cytochrome CYP3A4 isoenzyme system. The client also takes phenobarbital, an inducer of the CYP3A4 isoenzyme system, for seizures. What does the nurse recognize about diltiazem?
It might be inactivated at a faster rate than normal.
A client is receiving an antibiotic with the potential for nephrotoxicity. Which item should the nurse plan to monitor?
Plasma levels of the drug.
The nurse is reviewing the concept of a drug’s half-life for a student nurse, explaining that it is the time it takes for what to happen?
One - half of the drug to be eliminated by the boy.
