Lifespan Flashcards
Teratogenic
Birth defect!!
Teras-monster
Teratogenic: to create a monster
When do women need to use meds during prego?
Pre-existing Illness
Complications r/t pregnancy
Thx of conditions unrelated to pregnancy
When possible, drug therapy is postponed until after pregnancy and lactation. Which acute and chronic conditions must be managed during pregnancy?
Epilepsy
Std
Gestational diabetes
HTN
Pharmacokinetics of prego!? ADME
A- increases
D- increases
M- variable
E- increases
The nurse educator is explaining the factors that impact the transfer of medications across the placenta. Which factor would be responsible for higher concentrations of a drug being transferred to the fetus through the placenta?
Plasma drug concentration of mother
RISK FACTORS
A
Must take these; adequate well-controlled studies in pregnant women have not shown an inc. risk of fetal abnormalities to the fetus in any trimester.
Prenatal multivitamins, insulin, thyroxine, folic acid
RISK FACTORS
B & C
B-Animal studies have no incidence of harm to fetus, however no well controlled studies on women. OR animal studies have shown an adverse effect, but adequate and well controlled studies in prego women have failed to demonstrate risk to fetus.
EX. Penicillin/ibuprofen/acetaminophen/azyrhromycin.
C-animal studies have shown an adverse effect and there are no adequate and well controlled studies for women OR no animal studies and no adequate studies in prego women.
EX. Most prescription meds, anti microbial a such as clarithromycin.
RISK FACTORS
D
ONLY if mom’s life is in danger.
All adequate studies have demonstrated risk to fetus BUT the risk outweighs the potential risk.
EX. ACE inhibitors, alcohol, alprazalam, angiotensin receptor blockers
RISK FACTORS
X
Adequate studies show only fetal abnormalities and risks.
EX. Clomiphene, statins, testosterone, warfarin…
Student nurses are learning about the FDA pregnancy categories. What is the BEST information for the nurse educator to include?
Cat provide a framework for safe use of drugs in prego women
Cat X has been assoc with teratogenic effects.
A prego client tells a nurse at the first prenatal visit that she heard it is good to take an OTC iron prep during prego. Which statement by the nurse would be the best response?
“Safe to take iron during prefo, but tell your health care provider you are using it: many of them already contain iron
Pharmacotherapy of ped’s patients
A-increase D- increases (Inc d/t surface area of mass) M- decrease E- decreased (M/E are dec due to immature organs)
= lower doses! For peds
Infant who was prescribed and anti-infective gentamicin is brought to the ED with oliguria, hematuria, cloudy urine, fever. Which diagnosis would the nurse anticipate to find?
Neohrotixicuty
Children are given drugs in
Mg/kg
Dec metabolism and excretion in infants leads to
Longer time for IV to get OUT of body (dec M&E)
Faster peak in drug (inc A&D)
