Pharmacodynamics

Question 1

Most common protein to bind to..

Answer 1

Albumin

Question 2

Inter-Patient Variability

Answer 2

ED50 Effective dose for 50% of population.

Question 3

Therapeutic Indix

Answer 3

Compares ED50 and LD50 (lethal dose). Large therapeutic TI = low risk for toxicity while small TI = risk for toxicity and need plasma monitoring.

Question 4

High therapeutic indix =

Answer 4

wide therapeutic range

Question 5

Dose-response relationships

Answer 5

Can’t just increase dose and response…

Allergies are different; an exaggerated immune response.

Question 6

Potency

Answer 6

How strong a drug is based on dose. Higher dose = lower potency, lower dose= higher potency.

Question 7

Efficacy

Answer 7

Intensity of drug response… morphine works more intensely at reducing pain than ibuprofin so it has higher efficacy.

Question 8

Down regulation

Answer 8

Concept of drug tolerance… need an increase in drug dose to get the same response.

Question 9

Upregulation

Answer 9

Ex. Beta Blocker to decreases HR….up-regulation due to receptors requires pt to wean off meds.

Question 10

Agonist

Answer 10

Binds to receptor appropriately

Question 11

Partial agonist

Answer 11

Partially binds bud not fully so elicits a partial response.

Question 12

Antagonist

Answer 12

Blocks what body would normally do

Question 13

Agonist plus antagonist

Answer 13

Also has partial response like partial.

Question 14

Pharmacogenetics

Answer 14

G6PD Deficiency