Pharmacokinetics

Question 0

How do drug conc decline?

Answer 0

In a non linear fashion

Question 1

Pharmacokinetics

Answer 1

How body deals with drug

Absorption, distribution, metabolism, excretion

Question 2

Half life

Answer 2

Time it takes for drug conc to drop by half

Tells you how drug behaves

Question 3

What is the Cp power 0?

Answer 3

Conc at 0 time

Question 4

How many half life’s till drug gets to 3.13% (essentially left the body)?

Answer 4

5 half lives

Question 5

Half life of ameomerone= 45days. How long does it take to leave the body?

Answer 5

8 months (ish)

Question 6

Ideal half life?

Answer 6

24hrs

Question 7

Half life of warfarin? Why is this good?

Answer 7

36hrs. Can be taken once a day, more patient compliance.

Question 8

Define ‘1st order process’

Answer 8

Half life & rate of decline is dependant on concentration of drug

Question 9

Volume distribution=

Answer 9

Dose ✖️ Cp0

Question 10

Clearance of drug=

Answer 10

Dose ➗ area under curve

Question 11

What is the area under the curve at low clearance?

Answer 11

Area under curve is high

Question 12

Why does ameomerone have a long half life?

Answer 12

Vol of distribution is very high

Question 13

Slope of line=

Answer 13

Elimination rate constant (kel)

Question 14

Kel=

Answer 14

Elimination rate constant (slope of line)

Question 15

Blood clearance =

Answer 15

Vol of blood cleared of drug in unit time

Cl= Vd ✖️ kel (slope of line)

Sum of metabolic & renal Cl

Area under curve

Question 16

CL=

Answer 16

Dose ➗ area under curve

Vd ✖️ kel

Question 17

What happens to area under curve if dose doubles?

Answer 17

It doubles

Question 18

What happens to AUC if clearance is halved?

Answer 18

It doubles

Question 19

Kinetics of accumulation is the same as kinetics of ………..

Answer 19

Elimination

Question 20

How many half life’s till a drug reaches a steady state?

Answer 20

5 (same as elimination!)

Question 21

What predominates in phase 1?

Answer 21

Distribution

Question 22

What predominates in phase 2?

Answer 22

Elimination

Question 23

Half life of heparin?

Answer 23

1. 5hrs

7. 5 hrs to disappear

Question 24

T 1/2 (half life) =

Answer 24

0. 693 ➗ kel

0. 693 is natural log of 2 so use to find half life

Question 25

Cp (ss) = conc at a steady state =

Answer 25

Infusion rate ➗ Cl

Bioavailability✖️dose) ➗ (CI✖️dosing interval

Question 26

What do you do to infusion rate in patients with heart failure?

Answer 26

Decrease it

Question 27

What does Cp (ss) stand for?

Answer 27

Conc at a steady state

Question 28

Km=

Answer 28

1/2 Vmax