Bloodborne Viruses

Question 0

What are the main Hep C transmission routes?

Answer 0

From high to low:
Sporadic
IV drugs
Sexual 
Transfusion (4%)

Question 1

What are the 3 hepatitis viruses that are blood borne?

Answer 1

B, C, D

A is food borne

Question 2

Name clinical manifestations of Hep C

Answer 2

Iceterus (yellow sclera then skin)
Palmer erythema
Ascites- plasma from portal vein enters abdominal cavity
Thin skin

Question 3

Why are liver tumours painful?

Answer 3

The liver is in a capsule so cannot expand (eg a tumour growth) without causing severe pain

Question 4

What is the smallest enveloped DNA virus?

Answer 4

Hep B virus (42nm)

Question 5

Who can Hep B infect?

Answer 5

Humans & Chimps

Question 6

How does the Hep B virus replicate?

Answer 6

Via RNA intermediates using a reverse transcriptase

Question 7

What forms the envelope of Hep B virus?

Answer 7

S (surface, soluble), L & M proteins

Lipid

Question 8

What protein will you have antibodies for if you have been vaccinated against Hep B?

Answer 8

S

Question 9

What antibodies will you have if you have a history of Hep B?

Answer 9

S, E & C

Question 10

Name the family & genus Hep C belongs to

Answer 10

Family = Flaviviridae

Genus= hepacivirus

Question 11

What virus is the primary cause if liver cancer?

Answer 11

Hep C

Question 12

What happens to the CD4 count in HIV patients over time?

Answer 12

It decreases

Question 13

Name the surface protein of HIV

Answer 13

Surface glycoprotein gp120

Question 14

What cells do the HIV virus destroy?

Answer 14

T cells