CR: Too many lymphoid cells Flashcards
Normal platelet levels?
150-400 ✖️ 10 power 9
What is normal Hb in women & men?
What do B cells secrete?
IgM at first
Change to Igg when they become memory cells
Main protein in serum?
Albumin
Lymphocytosis
Raised lymphocyte count
Lymphocytes= T & B cells
Above normal =
1-4.5 ✖️ 10 power 9
What is the main virus that causes lymphocytosis?
EBV
Where are defects in acute leukaemia?
Early B cell precursors
Where do malignancies occur in lymphoma/ chronic leukemia?
Mature cells
Myeloma
Malignancy of terminally differentiated B lymphocytes (these cells secrete Ig)
Malignancy if plasma cells
How can myelomas damage bones?
Ball if malignant plasma cells
Recruit osteoclasts that ‘eat bone’
Holes
Fractures - pain on weight baring regions
Other features of myeloma (end organ damage)
Renal impairment- myeloma kidney caused by Ig damage
Hypercalcaemia- bone lysis
Recurrent infection
Anaemia
‘CRAB’
MGUS
Paraprotein in urine
No end organ damage
Myeloma prognosis
In curable malignancy
Chemo
Bidphisphonates
Reduce infections/renal failure/ skeletal events/ pain
What is the communist malignancy in haematology?
Myeloma
Lymphomas
Malignant conditions of lymph system
Clonal proliferations of mature lymphoid cells
