Drug Excretion

Question 0

What is renal blood flow in ml/min?

Answer 0

700

Question 1

What % of CO does kidney receive?

Answer 1

20%

Question 2

What is the GFR in ml/min?

Answer 2

125ml/min

20% of RBF

Question 3

What are the 3 ways drugs can be excreted via the kidney?

Answer 3

Glomerular F

Proximal tubular active S

Distal tubular passive R

Question 4

What molecules does glomerular filtration allow to cross into the filtrate?

Answer 4

Free unbound drug

Drug bound to plasma proteins will not

Question 5

What is the main treatment for gout?

Answer 5

Allopurinol

Question 6

Name an aminoglycoside antibiotic

Answer 6

Gentamicin

Question 7

Name drugs excreted to a large extent by glomerular filtration so can cause toxicity in kidney failure

Answer 7

Atenolol
Digoxin 
Allopurinol 
Diuretics 
Some ACE inhibitors
Aminoglycoside antibiotics 
Lithium

Question 8

What is used to measure glomerular filtration?

Answer 8

Creatinine clearance

Usually falls with increasing age

Question 9

What is the main cause if decreased renal function in the elderly?

Answer 9

Atherosclerosis of vessels

Question 10

What is ethanol metabolised to that cause sickness?

Answer 10

Acetaldehyde