Blood Transfusion & Haemolytic Anaemia Flashcards
What are RBCs stored in to make it last longer?
Optimal additive solution
Name the 5 blood components
RBCs
Platelets
FFP
….
What is the shelf life of RBCs?
35 days
RBCs must be compatible with what in the recipient?
The ABO type
What does RBC irradiation do?
When is it required most?
Prevents passenger lymphocytes from engrafting in host
Damages lymphocytes so they cannot replicate & caused harm
Required in foetuses & haematology patients
What reduces CMV infection?
By using CNV negative blood components
Risk ⬇️ by leucodepletion
2 typical settings for transfusion:
Blood loss
Anaemia
When is FFP used?
To treat factor deficiencies
To reverse the action of warfarin (contains clotting factors)
Massive transfusion
Liver disease (when not making clotting factors)
What are the 2 main uses of FFP?
DIC
Massive transfusion
Why must FFP given to a patient be ABO compatible?
To avoid haemolysis
Shelf life of platelets at room temp
5 days
Intra- uterine destruction on newborn RBCs is caused by mother making….
Anti- D which crosses placental barrier
Haemolytic anaemia is characterised by….
Inc in RBC turn over
Inc reticulocytes
Clinical features if H anaemia
Mild Jaundice
Pale
Pallor
