NSAIDS Flashcards
Somatoscisation
Emotional pain causing physical pain
Define pain
Unpleasant sensory and emotional experience which we primarily associate with tissue damage or describe in terms of such damage, or both
Name the 3 components of pain
Sensory discriminatory comp
Motivational- affective comp
Cognitive- evaluative comp
Describe the steps in feeling pain
Receptor activation (noiciceptors) Mediated by A-delta & C fibres
Describe A delta fibre
Thin, quick
Sharp localised pain
Withdraw hand
Describe C fibres
Thick, myelinated
Dull throbbing pain
Name NTs involved in pain pathways/ modulation/ transmission
Substance P Serotonin Histamine ACh Glutamate NA
What do endorphins regulate?
Regulate response to pain and stress
Endogenous opioid
What is somatic pain
Can localise pain
Usually involves organs/ systems
Describe somatic pain sensations
Aching, squeezing, stabbing, throbbing
What axons are activated in somatic pain?
Primary sensory afferents
What is stimulated in visceral pain?
Afferent receptors located in the viscera
Ill defined, cramping, gnawing, can be referred
Where can biliary referred pain be felt?
The shoulder
Name some NTs that are inflammatory mediators
Substance P
Serotonin
Bradykinin
Histamine
What is the role of prostaglandins in inflammation?
Enhances noiciceptive response to inflammation by lowering threshold to noxious stimuli
Causes to pain!
