Pharmacodynamics Flashcards
What is pharmacodynamics?
The understanding of how drugs interact with biological systems to produce their effects.
What are the three types of effects in pharmacodynamics?
Desired, side and adverse
What are the four types of receptors in pharmacodynamics?
Inotropic, G-protein, kinase-linked and nuclear
What are channel blockers?
When the drug blocks permeation of the channel by sitting in it and preventing passage of other ions and chemicals
What are channel modulators?
When the drug binds to a receptor site within the ion channel and modulates permeation.
What are enzymes?
Biological catalysts that increase the rate of chemical reactions in the body
What are transport systems?
They are distinct from plasma transport and are located on the cells in many areas of the body - they are also known as carrier molecule interactions
What is the concept of affinity?
Drugs have specific affinity for their receptors or chemical targets - this tells us how well a drug can bind to its target
What are agonists?
Drugs that bind to their target and fork a drug-receptor complex, the agonists activate the receptors to produce a response
What are antagonists?
Drugs that bind to their targets and form a drug-receptor complex but without activating a response - instead they can block the normal function of a receptor
What does ibuprofen target?
Cyclo-oxygenase 2
What is caused when COX-1 and COX-2 inhibit in enzymes?
Renal function homeostasis
What occurs when only COX-1 inhibits in an enzyme?
Gastric mucosa
What occurs when only COX-2 inhibits in an enzyme?
Pain, inflammation and fever
What is the definition of potency?
The comparison of the dose at which the drugs in the same class start to create a clinical response
