Pharmaceutical Materials Flashcards
Parts of a drug
Active ingredient and excipients
Properties of a solid dosage formulation depend on …..
Chemical composition and solid structure of both drugs and excipients
What does using a different solid form of the same drug do
Alters the bioavaliability of the drug
Alters the stability of dosage forms
Influence the way in which the dosage forms can be processed and manufactured
Important for the regulatory control of drugs and dosage forms
Bioavailability defition
% of dosage that enters the systemic circulation
A drug must be in .. before it can cross the GIT wall
Solution
Different physical forms may have different:
Stabilities, chemical reactivities, flow, compression and water sorption properties
Molecule?
Entity containing a number of atoms held by covalent bonds
Particle?
Microscopic structure containing millions of molecules held by non-covalent bonds
Powder?
Visible mass of particles
Crystalline materials
Ordered, periodic arrangement.
Unit cell repeated in 3D’s
Have a melting point
Amorphous materials
No long range order
Non-random local structure
Have a glass transition temperature
What do crystal systems do
Reflect symmetry of arrangement of mols in the crystal
Used to identify solid forms of rugs
Most drugs are triclinic, monoclinic or orthorhombic
Polymorphism
Different crystal structures of the same compound
Diffent MP and solubility’s but the same solution/melt
Polymorph stability
At a given T and P only one form can be stable - the one with the lowest free energy (G)
Monotropic relationship
The same form is stable irrespective of temperature
Enantiotropic relationship
Either of the 2 forms may be stable depending on the temperature