CaV And Hypertensio Flashcards

1
Q

Types of CaV channels

A

• L-type (CaV1) -> 1.1, 1.2, 1.3, 1.4
• P/Q-type (CaV2.2)
• N-type (CaV2.1)
• R-type (CaV2.3)
• T-type (CaV3)
• L-type consists of 4 genes encoding
different α1 subunits

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2
Q

What is Ca2+ important for

A

Cardiac and smooth muscle contraction

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3
Q

L-type Ca channels

A

(CaV1.2 and CaV1.3)
Found in the heart ad in vascular smooth muscle

Drugs acting on these can be used to control heart rate and vascular tone (dampe done the CaV)

They are Ca channel blockers - antagonists

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4
Q

Pharmacology of CaV Chanel’s

A

• Phenylalkylamines – verapamil - preferential for heart
• Dihydropyridines – nifedipine - preferential for hypertension
• Benzothiazepines - diltiazem

These drugs can cause AV block and cardiac slowing
These drugs can induce arteriolar dilatation and reduce blood pressure – act as vasodilators
Side effects – flushing, headaches, ankle swelling, cardiac rhythm, constipation
Linked to blocking CaV channels in other locations

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5
Q

CCB

A

Ca channel blockers

Bind to a1 subunit

interfere with voltage-dependent cycling between
resting –> open–> inactivated states

Higher affinity binding occurs to the open state or inactivated state

IIIS5, IIIS6 and IVS6 segments are major areas of drug binding

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