Pharm- Tetracylines

Question 1

Tetracycline GI absorption is _____ in the presence of foods

Answer 1

decreased

Question 2

MOA of tetracyclines

Answer 2

Reversibly blocks the 30s ribosome to prevent protein synthesis

Question 3

effective against resistant strains as a consequence for not being a substrate for the efflux pump

Answer 3

Doxycycline, minocycline and tigecycline

Question 4

Tetracyclines enter susceptible bacterial in part by ________ and through __________

Answer 4

simple diffusion, active transport

Question 5

effective even against the Tet (A) efflux-expressing gram –ve strains having resistance to the older tetracyclines (doxycycline and minocycline)

Answer 5

Tigecycline

Question 6

In staphylococcus the Tet (K) confers resistance to tetracyclines but not to

Answer 6

doxycycline, minocycline or tigecycline

Question 7

Tet (M) ribosomal protection expressed by gram +ve strains confers resistance to tetracyclines, doxycycline, and minocycline, but not to

Answer 7

tigecycline

Question 8

Absorption is not effected by food

Answer 8

doxycyline and minocycline

Question 9

Highest absorption

Answer 9

doxycyline and minocycline (95-100%)

Question 10

lowest absorption

Answer 10

chlortetracycline

Question 11

attain high concentrations in saliva and tears making it useful for eradication of the meningococcal carrier state

Answer 11

Minocycline

Question 12

eliminated via non-renal mechanisms and their doses adjustments are not required in renal failure

Answer 12

Doxycycline and tigecycline

Question 13

Short-acting (6-8 hours)

Answer 13

Chlortetracycline, tetracycline and Oxytetracycline

Question 14

Intermediate acting (12 hours)

Answer 14

Demeclocycline and Methacycline

Question 15

Long – acting (16 – 18hrs)

Answer 15

Doxycycline, and minocycline

Question 16

Has a half life of 36hrs

Answer 16

Tigecycline

Question 17

Tetracyclines may be used in combination with a __________ and other agents to treat Helicobacter pylori-induced ulcers

Answer 17

proton pump inhibitor

Question 18

Used against sensitive _____infections and has rapid actions against _______

Answer 18

vibro , cholera

Question 19

_________may be used in certain ADH secreting tumors

Answer 19

Demeclocycline

Question 20

Has a broad spectrum and is effective against many tetracycline-resistant strains
administered i.v.

Answer 20

Tigecycline

Question 21

Tetracyclines are deposited in ___________ and are contraindicated in children > 8yrs old and pregnant women

Answer 21

bone and teeth

Question 22

Clindamycin MOA

Answer 22

Binds exclusively to the 50S ribosome and inhibit protein synthesis

Question 23

Penetrate well into abscesses and concentrate in phagocytic cells via active transport

Answer 23

Clindamycin

Question 24

MOA of chloramphenicol

Answer 24

Inhibits bacterial 50S ribosomes and prevent protein synthesis

Question 25

Active against rickettsia but not Chlamydia

Answer 25

Chloramphenicol

Question 26

Indicated for serious rickettsial infection such as typhus and rocky mountain spotted fever

Answer 26

chloramphenicol

Question 27

an alternative to -lactam against meningococcal meningitis

Answer 27

Chloramphenicol

Question 28

has adverse effect of bone marrow distrubance, as well as gray baby syndrome

Answer 28

Chloramphenicol