Microbiology- Autoimmune Diseases of the Musculoskeletal System Flashcards
B27 rr = 87.4
Ankylosing Spondylosis
Type II Non-cytotoxic disease
Myasthenia Gravis
Type III hypersensitivities
Rheumatoid Arthritis
Systemic Lupus Erythematosis
Type IV
Multiple Sclerosis
MOA of Myasthenia Gravis
Auto-antibodies specific for the acetylcholine receptor
MOA of Rheumatoid Arthritis
RF- IgM binds Fc of IgG, WBC infiltration, destruction of joint
MOA of Systemic Lupus Erythematosis
Ab bind tissue, complexes form, complement binds, inflammation, necrosis; butterfly rash on face (can be triggered by sun)
MOA of Multiple Sclerosis
T cells recognize Myelin Basic Protein and attack myelin sheath; sclerotic plaques that secrete IgG in CSF
MOA of Ankylosing Spondylosis
Abs against klebsiella, shigella, and Yersinia react with the spine, eventual spinal fusion
MOA of Reiter’s Syndrome
Reactive arthritis triggered by infections of Chlamydia, Yersinia, and Shigella
_____ controls the proliferation of T cells by binding to_____ and subsequently blocking the __________
CTLA-4, B7, activation signal
Mutations in _____(codes for regulatory T cells (Treg)= increased chance of autoimmune disease
FoxP3
SLE patients have increased ____, which induces ______, resulting in __________
IFN-γ, MHC II, T cell activation against self antigens
_____bypasses the specificity of the Fc region and gets to the B cell via CD21
EBV, CMV
_______ in ______ results of decreased self antigen in the thymus
Decreased, AIRE
