Path- Bon, Cartilage, and Soft Tissue

Question 1

How do you distinguish between Morquio syndrome and cretinism

Answer 1

(a) To distinguish between this and Cretinism: Both have shorter stature and significant mental retardation, but in Morquio, there are dental defects

Question 2

what is an important causative agent in patients with sickl cell anemia

Answer 2

Salmonella

Question 3

what is the most common bacteria in osteomyolitis, name some others as well

Answer 3

Staphylococcus aureus, pneumococci, and group B strep in neonates

Question 4

what is the most common primary site for metastatic bone tumors

Answer 4

prostate

Question 5

what is the most common soft tissue tumor of adulthood and where does it have its effect, and benign or malignant

Answer 5

lipoma, subcutaneous, benign

Question 6

name a difference between leiomyoma and leiomyosarcomas

Answer 6

leiomyoma NEVER progress to being malignant, while leiomyosarcomas are ALWAYS malignant

Question 7

Leiomyosarcomas_________ from a leiomyoma–> Derived from ___________

Answer 7

Leiomyosarcomas do not evolve from a leiomyoma Derived from 2 different cell types, 2 different cell types

Question 8

More common form of Morquio syndrome

Answer 8

Type A- don’t have enough NAG-6 sulfate sulfatase

Question 9

most common disease of the growth plates, autosomal dominant defect in paracrine signaling

Answer 9

Achondroplasia

Question 10

inheritance of osteogenesis imperfecta

Answer 10

Autosomal dominant

Question 11

Vertebral compression fractures are common in patients with _______ and is due to loss of _________

Answer 11

osteoperosis, trabecular bone

Question 12

Most common instances of osteoperosis

Answer 12

Senile and post-menopausal

Question 13

1 problem with Paget’s disease

Answer 13

bone pain due to microfractures and bone overgrowth

Question 14

Most common complication of paget’s

Answer 14

long bones of lower extremity

Question 15

Primary bone tumors are ______ common than metastatic lesions

Answer 15

less

Question 16

where are osteomas most commone

Answer 16

head and neck

Question 17

most common malignant tumor of the bone

Answer 17

osteosarcoma

Question 18

Secondary osteosarcoma occurs in older individuals most commonly in the setting of ________

Answer 18

Paget Disease

Question 19

Most common benign bone tumor (1/3)

Answer 19

Osteochondroma

Question 20

commonyl occurs in central portion of skeleton in the shoulders and pelvis

Answer 20

Chondrosarcoma

Question 21

d) Following osteosarcoma, these are second most common form of bone tumor in children

Answer 21

Ewing sarcomas

Question 22

most common disorder of joints

Answer 22

osteoarthritis

Question 23

i) Common intraarticular crystal formation

Answer 23

pseudogout

Question 24

i) Most common soft tissue sarcoma in children and adolescence (prior to age 20)

Answer 24

Rhabdomyosarcoma