Path- Autoimmune Diseases

Question 1

mildest form of Lupus glomerulonephritis, great prognosis

Answer 1

Mesangial Lupus GN

Question 2

epithelial cresents present, progresses to renal failure, most serious Lupus Gn

Answer 2

Diffuse Proliferative Lupus GN

Question 3

Describe the respiratory symptoms of Lupus (according to Mayo clinic)

Answer 3

Dyspnea, asthma-like wheezing, and chest pain during physical activity

Question 4

Most common cardiac disease related to lupus

Answer 4

Pericarditis

Question 5

o Vegetations over the mitral valve surface and even on the chordae tendineae (chordae are fused and thickened)

Answer 5

Libman Sacks

Question 6

Why do we not really worry about Libman Sacks?

Answer 6

only in 4% of lupus patients, and are not large and rarely embolize

Question 7

In Drug-induced lupus, antibodies to_____ gives a ________ test

Answer 7

Histones, (+) ANA

Question 8

In PSS, antibody to ____ is most common

Answer 8

Scl-70

Question 9

Describe the MOA of PSS

Answer 9

Arteries, arterioles and capillary destruction (increased vascular permeability) leading to fibrosis, narrowing, renin release, and hypertension

Question 10

Early symptoms/stages of Generalized Progressive System PSS

Answer 10

Secondary Raynauds
1- lack of blood flow= white
2- vessel dilation= blue
3- hyperemia= red

Question 11

Name two characteristics of polymyositis

Answer 11

adults aged 40-50s, and DOES NOT involve cutaneous system

Question 12

Mixed Connective Tissue Diseases:
Antibody directed to ______
Not directed towards ______
Nuclear proteins include ___ and ____

Answer 12

U1 ribonucleoprotein
ds-DNA
Jo-1, PM-1

Question 13

Nucleolar pattern of antibodies specific for Scl-70

Answer 13

PSS- Scleroderma

Question 14

Top 4 Type II Non-Cytotoxic Diseases

Answer 14

Myasthenia Gravis, Grave’s disease, Pernicious anemia, Diabetes Mellitus (Type II)

Question 15

a ____ pattern in immunofluoresence tagged to ______ is characteristics of SLE

Answer 15

Rim, ds-DNA

Question 16

often the first syndrome in SLE, and effects __% of patients affected

Answer 16

Polyarthralgia Inflammatory Synovitis without joint destruction

Question 17

when thinking of SLE symptoms, be thinking of

Answer 17

skin, joints, kidneys, lungs, and heart

Question 18

~ 33% of lupus patients have inceased concentrations of ___________ which leads to thromboembolisms, and is known as

Answer 18

antiphospholipid Ab, • Antiphospholipid Antibody Syndrome

Question 19

o These vegetations appear in about 4% of SLE patients and rarely cause problems because they are not large and rarely embolize, involve _______ and ____ of the chordae

Answer 19

Libman Sacks Endocarditis, fusion and thickening

Question 20

2 differences between SLE and drug-induced lupus

Answer 20

no sex predominance (SLE-women)

no CNS or renal

Question 21

2 differences between DLE and SLE

Answer 21

DLE only affects the skin, and no other organ systems

Antibodies are only in skin that contains a rash

Question 22

Circular rash is indicative of

Answer 22

DLE

Question 23

 Papular and anular rings on trunk
• Aggravated by sunlight
 Will only see immunofluorescence in skin with rash (not systemic)

Answer 23

Subacute Cutaneous Lupus

Question 24

2 symptoms of PSS

Answer 24

Keratoconjunctivitis
Xerostomia
bilateral parotid gland enlargement

Question 25

In PSS you are 40x as likely to develop______

Answer 25

lymphoma

Question 26

MOA for PSS and its effects on the _____and ______

Answer 26

skin ,kidneys | vascular destruction and increase in permeability, fibrosis and narrowing of vessels, releases renin and hypertension

Question 27

CREST

Answer 27

``` Calcinosis Raynaud phenomenon Esophageal dysmotility Sclerodactyly Telangiectasia ```

Question 28

2 presentations of dermomyositis

Answer 28

Lilac rash- upper eyelid with periorbital edema | Grotton Lesions- • Erythematous patches over knuckles

Question 29

myositis characterized by weakness of limb and neck muscles and much muscle pain

Answer 29

polymyositis