Path- Autoimmune Diseases

Question 1

mildest form of Lupus glomerulonephritis, great prognosis

Answer 1

Mesangial Lupus GN

Question 2

epithelial cresents present, progresses to renal failure, most serious Lupus Gn

Answer 2

Diffuse Proliferative Lupus GN

Question 3

Describe the respiratory symptoms of Lupus (according to Mayo clinic)

Answer 3

Dyspnea, asthma-like wheezing, and chest pain during physical activity

Question 4

Most common cardiac disease related to lupus

Answer 4

Pericarditis

Question 5

o Vegetations over the mitral valve surface and even on the chordae tendineae (chordae are fused and thickened)

Answer 5

Libman Sacks

Question 6

Why do we not really worry about Libman Sacks?

Answer 6

only in 4% of lupus patients, and are not large and rarely embolize

Question 7

In Drug-induced lupus, antibodies to_____ gives a ________ test

Answer 7

Histones, (+) ANA

Question 8

In PSS, antibody to ____ is most common

Answer 8

Scl-70

Question 9

Describe the MOA of PSS

Answer 9

Arteries, arterioles and capillary destruction (increased vascular permeability) leading to fibrosis, narrowing, renin release, and hypertension

Question 10

Early symptoms/stages of Generalized Progressive System PSS

Answer 10

Secondary Raynauds
1- lack of blood flow= white
2- vessel dilation= blue
3- hyperemia= red

Question 11

Name two characteristics of polymyositis

Answer 11

adults aged 40-50s, and DOES NOT involve cutaneous system

Question 12

Mixed Connective Tissue Diseases:
Antibody directed to ______
Not directed towards ______
Nuclear proteins include ___ and ____

Answer 12

U1 ribonucleoprotein
ds-DNA
Jo-1, PM-1

Question 13

Nucleolar pattern of antibodies specific for Scl-70

Answer 13

PSS- Scleroderma

Question 14

Top 4 Type II Non-Cytotoxic Diseases

Answer 14

Myasthenia Gravis, Grave’s disease, Pernicious anemia, Diabetes Mellitus (Type II)

Question 15

a ____ pattern in immunofluoresence tagged to ______ is characteristics of SLE

Answer 15

Rim, ds-DNA

Question 16

often the first syndrome in SLE, and effects __% of patients affected

Answer 16

Polyarthralgia Inflammatory Synovitis without joint destruction

Question 17

when thinking of SLE symptoms, be thinking of

Answer 17

skin, joints, kidneys, lungs, and heart

Question 18

~ 33% of lupus patients have inceased concentrations of ___________ which leads to thromboembolisms, and is known as

Answer 18

antiphospholipid Ab, • Antiphospholipid Antibody Syndrome

Question 19

o These vegetations appear in about 4% of SLE patients and rarely cause problems because they are not large and rarely embolize, involve _______ and ____ of the chordae

Answer 19

Libman Sacks Endocarditis, fusion and thickening

Question 20

2 differences between SLE and drug-induced lupus

Answer 20

no sex predominance (SLE-women)

no CNS or renal

Question 21

2 differences between DLE and SLE

Answer 21

DLE only affects the skin, and no other organ systems

Antibodies are only in skin that contains a rash

Question 22

Circular rash is indicative of

Answer 22

DLE

Question 23

 Papular and anular rings on trunk
• Aggravated by sunlight
 Will only see immunofluorescence in skin with rash (not systemic)

Answer 23

Subacute Cutaneous Lupus

Question 24

2 symptoms of PSS

Answer 24

Keratoconjunctivitis
Xerostomia
bilateral parotid gland enlargement

Question 25

In PSS you are 40x as likely to develop______

Answer 25

lymphoma

Question 26

MOA for PSS and its effects on the _____and ______

Answer 26

skin ,kidneys

vascular destruction and increase in permeability, fibrosis and narrowing of vessels, releases renin and hypertension

Question 27

CREST

Answer 27

Calcinosis
Raynaud phenomenon
Esophageal dysmotility
Sclerodactyly
Telangiectasia

Question 28

2 presentations of dermomyositis

Answer 28

Lilac rash- upper eyelid with periorbital edema

Grotton Lesions- • Erythematous patches over knuckles

Question 29

myositis characterized by weakness of limb and neck muscles and much muscle pain

Answer 29

polymyositis