PHARM - pharm of cognitive dysfunction Flashcards
1
Q
three attentional networks
A
executive - anterior cingulate
orienting - parietal, frontal eye fields, colliculus
alerting - thalamic, right frontal, parietal
2
Q
what are the commonly used pro-cholinergic agents used for cognition?
A
ACh-esterase inhibitors - donepezil - rivastigmine - galantamine ACh precursors - CDP-choline
3
Q
donepezil is FDA approved for …….
A
alzheimers
4
Q
other conditions in which ACh-esterase inhibitors have show promise
A
TBI - methylphenidate
Down Syndrome with dementia
parkinsons - rivastigmine
dementia with lewy bodies
5
Q
what do we see on alzheimer’s imaging?
A
parietal atrophy
6
Q
catecholeminergic agents used for cognitive dysfunction
A
CNS stimulants - Methylphenidate - Dextroamphetamine Other agonists/antagonists - Clonidine - Guanfacine - Bromocriptine - Amantadine - Memantine Neurotransmitter re-uptake inhibitors - atomoxetine
7
Q
methylphenidate (ritalin) mechanism, contraindication
A
blocks reuptake of NE and DA
don’t use with MAOIs
8
Q
dextroamphetamine uses
A
- also used for ADD, may work when methylphenidate doesn’t
- potential efficacy in TBI
