Pharm- Diarrhea & Antispasmotic Flashcards
Metoclopramide- Indications
Antiemetic- chemotherapy
Metoclopramide- MOA
Dopamine receptor antagonist. Stimulates GI tract motility
Metoclopramide- AE
Sedation, diarrhea, extrapyramidal symptom
Dicyclomine- MOA
Anticholinergic- relaxes smooth muscle, inhibits bradykinin and histamine
Dicyclomine- Indications
IBS- antimotility agent
Dicyclomine- AE
Dry mouth, dizziness, blurred vision, psychosis, hallucination
Hyocyamine- MOA
Anticholinergiic- antagonizes acetylcholine
Hyocyamine- Indications
IBS, antispasmotic on smooth muscle
Hyocyamine- AE
Dry mouth, eyes, urinary retention, anaphylaxis
Antiparistaltic agents- MOA
Activate opioid receptors in enteric NS, decreaseing paristalsis and inhibiting acetylcholine
Antiparistaltic agents- Indications
Diarrhea control
Antiparistaltic agents-AE
Drowsiness, abd. Cramps, dizziness
Adsorbents- Indications
Diarrheal control, least effective
Adsorbents- MOA
Adsorb toxins & microorgs, coat and protect intestinal mucosa
Adsorbents- AE
Impaired absorption of other drugs