Antiemetics

Question 1

Prochlorperazine- MOA

Answer 1

Block dopamine receptors- antagonist

- Anticholinergic & antihistimenic

Question 2

Prochlorperazine- Indications

Answer 2

Motion sickness, migraines,

Question 3

Prochlorperazine- AE

Answer 3

• Hypotension, restlessness, extrapyramidal (tardive dyskinesia, dystonina) symptoms

Question 4

Odansetron (Zofran)- MOA

Answer 4

Selective 5HT3 inhibtion on brain and periphery

Question 5

Odansetron- Indications

Answer 5

Antiemetic- chemotherapy, First line for N/V

Question 6

Odansetron-AE

Answer 6

• Headache,
• prolonged QT interval
• constipation / dizziness

Question 7

Metoclopramide- Indications

Answer 7

Antiemetic- chemotherapy

- Cant use long term

Question 8

Metoclopramide- MOA

Answer 8

• Dopamine receptor antagonist. - Stimulates GI tract motility- promotility

Question 9

Metoclopramide- AE

Answer 9

• Sedation, diarrhea, - extrapyramidal symptoms

Question 10

Dronabinol- MOA

Answer 10

Cannabinoid- produces CNS effects

Question 11

Dronabinol- Indicaitons

Answer 11

Nausea & wt loss: AIDS, chemo, anorexia

- Appetite stimulant

Question 12

Dronabinol- AE

Answer 12

• Slows gastric emptying

Dizziness, somnolence, euphoria, addiction

Question 13

Promethazine- MOA

Answer 13

Binds to H1 reciptors blocking effect of histamine on CNS

Question 14

Promethazine- Indications

Answer 14

Nausea, vomiting, motion sickness

Question 15

Promethazine- AE

Answer 15

Drowsiness, sedation, blurred vision, apnea

Question 16

N/V non-pharmacologic Tx

Answer 16

• Clear liquid diet
• Small quantities of dry food
• Low fat