Disorders of absorption Flashcards

1
Q

Whipple disease- Eti

A
  • Rare multisystem illness
  • Bacillis Tropheryma whippelii
  • Unknown source of infection
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2
Q

Whipple disease- Sx

A
  • Abd pain, diarrhea, malabsorption with distension, flatulence & steatorrhea
  • Arthralgia
  • Lymphadenopathy
  • Wt loss
  • Myocardial involvement- murmurs
  • CNS involvement
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3
Q

Whipple disease- Dx

A
  • Endoscopic biopsy of duodenum- PAS macrophages

- PCR

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4
Q

Whipple disease- Tx

A

Cefttriaxone, TMP-sulfa

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5
Q

Short bowel syndrome- Eti

A
  • Malabsorption following small intestine resection

- Chrons, infarction, radiation, trauma

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6
Q

Short bowel syndrome- Sx

A
  • Low vit B12
  • Malabsorption of fat soluble vitamins
  • kidney stones
  • Watery diarrhea
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7
Q

Short bowel syndrome- Dx

A
  • Hx & symptoms
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8
Q

Short bowel syndrome-Tx

A
  • Vitamin supplements
  • Bile acid binding salts
  • low fat diet
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9
Q

Celiac sprue- Eti

A
  • 1:100 whites
  • Dx in 10%
  • ID at any age
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10
Q

Celiac sprue- Sx

A
  • Diarrhea, steatorrhea, wt loss, abd distension, weakness, muscle wasting
  • Dyspepsia, flatulence, wt loss
  • Fatigue
  • Iron anemia
  • Dermatitis herptiformis
  • Hyperactive bowel sounds
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11
Q

Celiac sprue- Dx

A
  • Endoscopic biopsy of duodenum

- IgA serology when consuming gluten

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12
Q

Celiac sprue- Tx

A
  • Remove gluten
  • Avoid dairy
  • Supplements
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13
Q

Acute diarrhea- Eti

A
  • Duration < 2-3 weeks
  • Commonly infectious- hx may reveal org.
  • Inflammatory or non
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14
Q

Acute Inflammatory diarrhea-Org

A
  • Shigellosis, salmonellaosis, campy, yersinia or toxin E.coli
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15
Q

Acute inflammatory diarrhea- Sx

A
  • Fecal leukocytes & blood

- LLQ cramps, urgency & tenesmus

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16
Q

Acute non-inflammatory diarrhea- Orgs

A
  • Viruses
  • preformed toxins (B. cereus, clostridium, S. aureus
  • Protozoa
17
Q

Acute non-inflammatory diarrhea- Sx

A
  • No blood or fecal leukocytes
  • Voluminous diarrhea, cramps, N/V
  • Dehydration, hypokalemia & acidosis
18
Q

Acute inflammatory diarrhea- Dx

A
  • O & P, culture and hx to determine org.

- Commonly self limited

19
Q

Acute diarrhea- Tx

A
  • Antidiarrheal in non-inflammatory
  • Abx
  • Opioids
  • Fluids & BRAT diet
20
Q

Chronic diarrhea- Eti

A

> 4 weeks

- Lactase deficiency?

21
Q

Chronic diarrhea- Sx

A
  • Osmotic, secretory, inflammatory or malabsorption
22
Q

Chronic diarrhea- Dx

A
  • Determine cause: med, organism,

- CBC, LFT, INR, Stool studies, colonoscopy

23
Q

Chronic diarrhea- Tx

A
  • Remove meds, foods that may cause

- Loperamide, tincture of opium, clonidine

24
Q

Constipation- Eti

A
  • Excessive difficulty defecating, straining
  • Fewer than 2 BM/ week
  • W>M
  • 10-15% adults
  • May be due to slowed GI tract or secondary to other systemic disease
25
Q

Constipation- Sx

A
  • Decreased appetite
  • Paradoxical diarrhea
  • Firm feces palpable on DRE
  • Abd pain & distensio
26
Q

Constipation- Dx

A
  • Empiric tx if no alarming symptoms
27
Q

Constipation- Tx

A
  • FIber
  • Osmotics
  • Surfactants
  • Stimulants
28
Q

Fecal impaction- Eti

A
  • Bowel obstruction due to feces

- Meds, spinal cord disorder, bed rest

29
Q

Fecal impaction- Sx

A
  • Decreased appetite
  • N/V
  • leakage
  • Firm feces palpable on DRE
30
Q

Fecal impaction- Tx

A
  • Enemas

- Digital disruption