GI Drugs

Question 1

H2 antagonisits- MOA

Answer 1

Blocks histamine receptors in stomach, reducing H+

Question 2

H2 antagonisits-Indications

Answer 2

GERD & peptic ulcers

Question 3

H2 antagonisits- AE

Answer 3

HA, dizziness, diarrhea, muscular pain, genecomastia & galacorrhea

Question 4

PPIs- MOA

Answer 4

H/K ATPase pump inhibitors

Question 5

PPIs- Indications

Answer 5

Preferred for ulcers, prophylazis, GERD and hypersecretpry disorders

Question 6

PPIs- AE

Answer 6

Malabsorption of B12, Increased risk of fracture

Question 7

Antacids- MOA

Answer 7

React with gastric acid to form water. Reduce pepsin activity

Question 8

Antacids-Indications

Answer 8

Symptomatic relief of peptic ulcers & GERD, promote healing of ulcers

Question 9

Antacids-AE

Answer 9

Constipation or diarrhea, systemic alkalosis, electrolyte accumulation

Question 10

Mucosal protectant agents- MOA

Answer 10

Inhibit activity of pepsim, increase protective mucous secretion

Question 11

Mucosal protectant agents- Indications

Answer 11

Healing of peptic ulcers

Question 12

Mucosal protectant agents- AE

Answer 12

Impaired absorption of other medications/ vitamins