Gastric disorders Flashcards

1
Q

Dyspepsia- Eti

A
  • 15% adult population
  • 3% office visits
  • Functional dyspepsia is most common
  • Ulcers in 5%
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2
Q

Dyspepsia- Sx

A
  • Epigastric pain/ burning
  • Postprandial fullness
  • Hx- chronic, location, qualatiy
  • N/V
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3
Q

Dyspepsia- Dx

A
  • Endoscopy
  • Test for H pylori
  • Imaging if complicated
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4
Q

Dyspepsia- Tx

A
  • PPI

- Reduce offending foods/ medications

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5
Q

Zollinger-Ellison syndrome- Eti

A
  • Gastrin- secreting neuroendocrine tumors (gastrinoma)
  • Hypergastrinemia & acid hyper secretion
  • Arise in pancreas duodenal wall, lymph or other locations
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6
Q

Zollinger-Ellison syndrome- Sx

A
  • Soliatry peptic ulcer in proximal duodenal bulb
  • GE reflux symptoms
  • Diarrhea, steatorrhea, wt loss
  • Metastases to liver
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7
Q

Zollinger-Ellison syndrome- Dx

A
  • Somatostatin receptor scintigraphy
  • Endoscopic ultrasonography
  • Secretin stimulation
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8
Q

Zollinger-Ellison syndrome- Tx

A
  • PPI

- Surgical removal of gastrinoma

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9
Q

Peptic ulcer disease- Risks

A
  • NSAIDs (steroids)
  • H. pylori
  • genetics
  • Renal failure, cirrhosis, & COPD
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10
Q

Peptic ulcer disease- Eti

A

5-10% population

  • Increase with age
  • 45% NSAIDs
  • 45% H. pylori
  • M>W
  • Smokers
  • 500,000 new cases/ year
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11
Q

Peptic ulcer disease- Sx

A
  • Sharp burning in upper quadrants, epigastric
  • Nausea
  • Hunger or fullness
  • Gastric- worse after eating
  • Duodenal- 2-3 hrs after eating, awaken from sleep
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12
Q

H. pylori- Risks

A
  • Developed countries
  • low socioeconomic
  • Acquired in first 10 yrs
  • Infected parents
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13
Q

Diabetic gastroparesis- Eti

A
  • Gastric obstruction due to endocrine dysfunction
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14
Q

Diabetic gastroparesis- Sx

A
  • Chronic or intermittent gastroparesis

- Early satiety, bloating, N/V 1-3 hrs after meals

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15
Q

Diabetic gastroparesis- Dx

A
  • Exclude mechanical obstruction

- Abd xray: dilation of stomach investing or colon resembling mechanical obstruction

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16
Q

Diabetic gastroparesis-

A
  • Maintina glucose < 200

- Small, frequent meals low in fiber, daily, & fat

17
Q

Erosive gastritis- Eti

A
  • Common in alcoholic, critically ill or NSAIDs
18
Q

Erosive gastritis- Sx

A
  • Asymptomatic
  • Coffee ground emesis, bloody aspirate, melena
  • Dyspepsia, anorexia, epigastric pain
19
Q

Erosive gastritis- Dx

A
  • Endoscopy
20
Q

Erosive gastritis- Tx

A
  • PPI

- Discontinue offending organism

21
Q

Pernicious Anemia Gastritis- Eti

A
  • Autoimmune disorder involving fundic gland

- Achlorhydria, intrinsic factor secretion, and B12 malabsorption

22
Q

Pernicious Anemia Gastritis- Sx

A
  • Hypergastremia

- Gland atrophy and interstitial metaplasia

23
Q

Pernicious Anemia Gastritis- Dx

A
  • Endoscopy biopsy
  • Anti-intrinsic factor
  • Macrocytic anemia
24
Q

Pernicious Anemia Gastritis- Tx

A
  • Screen for adenocarcinoma & carcinoids

- Vit B12

25
Q

H, pylori- Sx

A
  • Transient illness of nausea, abd pain and gastritis

- Diffuse mucosal inflammation

26
Q

H. Pylori- Dx

A
  • Fecal antigen assay
  • Urea breath test
  • Must discontinue PPI
27
Q

H. pylori- Tx

A
  • Triple tx: Omeprazole, calrithromycin and amox

- Quad tx: resistant disease

28
Q

Gastric malignancy- Eti

A
  • Adenocarcinoma most common
  • Gastric lymphoma due to H. pylori
  • M> W
  • Intestinal= envt, older 70-80%
  • Diffuse = hereditary, younger
29
Q

Gastric malignancy- Sx

A
  • Asymptomatic until advanced
  • Dyspepsia, epigastric pain
  • Anorexia, early satiety
  • Postprandial vomitin
30
Q

Gastric malignancy- Dx

A

Endoscopy

31
Q

Gastric malignancy- Tx

A

Surgical resection

32
Q

Hiatal hernia- Eti

A
  • Assoc with GERD, Barett esophagus

- Stomach protrusion through LES

33
Q

Hiatal hernia- Tx

A

Surgically tighten sphincter

34
Q

Nonspecific gastritis- Eti

A
  • H. pylori & associated with pernicious anemia
  • Eosinophilia
  • Diffuse mucosal inflammation