Pharm Antiviral for skin lesions, Nucleosides Flashcards
-Host cell kinases means the Host is having to do most of the work, which is not as effective -Viral activation, is much more effective
*Valcyclovir (prodrug thats oral) turns into what parent drug, and what is the viral activation? What type of analog?
Acyclovir. Herpes Simplex Virus/ HZV:Thymidine kinase, -mono P
-Guanosine analog
Valcyclovir cell activation
Host cell kinases -di P, -tri P
*Famciclovir (prodrug that oral) turns into what parent drug, and what is the viral activation? What type of analog?
Penciclovir (HSV ONLY). Herpes Simplex Virus/HZV thymidine kinase, -mono P
- FAMCICLOVIR CAN TREAT HSV AND VZV
- Guanosine analog
Famciclovir cell activation
-Host cell kinases -di P, -tri P
*Valganciclovir (prodrug thats oral) turns into what parent drug, and what is the viral activation? What type of analog?
Ganciclovir. CMV UL97 kinase, -mono P
-Guanosine analog
Valganciclovir Cell activation
Host cell kinases, -di P, -tri P
Cidofovir viral activation
none needed
*Cidofovir cell activation
HOST CELL KINASES, -mono p, -di P, -tri P
Vidarabine viral activation
None needed
Vidarabine cell activation and what type of analog
Host cell kinases -mono P, di P, -tri P
-Adenosine analog
Trifluroidine cell activation
host cell kinases, -mono P, -di P, -tri P
Trifluroidine viral activation
None needed
*Acyclovir uses
HSV, VZV (-Zoster)
*Valacyclovir uses
HSV, VZV
*Penciclovir uses
HSV only
