Pharm antineoplastic Agents III, Alkylate/Cross Link DNA

Question 1

Triazenes: Dacarbazine, procarbazine, temozolomide Funcitonal agent (bi or mono) and MOA

Answer 1

• Monofunctional Agents

- DNA Alkylation. Methylation, guanosine 0(6), N(7)

Question 2

Dacarbazine Uses

Answer 2

-Metastatic MELANOMA

Question 3

Procarbazine Uses

Answer 3

-Malignant GLIOMA

Question 4

Temozolomide Uses

Answer 4

-Treatment resistant GLIOMA and ASTROCYTOMA

Question 5

Carmustine and Lomustine MOA and Functional agent (bi or mono)

Answer 5

• GG cross links DNA alkylation. Alkylation, guanosine O(6), N(7)
• Bifunctional agent

Question 6

Streptozocin MOA and functional agent (bi or mono)

Answer 6

-Selective at islet Beta cells

Question 7

Carmustine and lomustine Uses

Answer 7

-Brain tumors, lymphoma, melanoma

Question 8

Streptozocin Uses

Answer 8

-Insulinomas (….but causes diabetes)

Question 9

**Cyclophosphamide toxicity

Answer 9

-ACROLEIN

Question 10

*Temoxolomide MOA

Answer 10

-Relies on MGMT nz (if high=uneffective, if low=then a good choice)