Pharm antineoplastic Agents III, Topoisomerase Inhibitors Flashcards
-Drugs that cause DNA strand breaks
1
Q
*Epipodophyllotoxins (class): Etoposide and teniposide (members) MOA and what cell cycle phase they work in
A
- TOPOISOMERASE II inhibition–DNA DOUBLE strand breaks
- “Toposiomerase II=Double”
- G2-phase
2
Q
Camptothecins (class): Irinotecan (SN38 active metabolite) and topotecan (members) MOA and what cell cycle phase they work in.
A
- TOPOISOMERASE I inhibition–DNA SINGLE strand breaks
- “toposiomerase I=Single”
- S phase
3
Q
*Etoposide Uses
A
- OAT CELL CARCINOMA
- Testicular cancer
4
Q
Teniposide Uses
A
-Efficiency vs glioma and neuroblastoma
5
Q
Irinotecan Uses
A
- Metastatic colorectal cancer
- “Iran takes it up the ass”
6
Q
**Iranotecan Dose limiting toxicity
A
-Severe diarrhea (life threatening)
