Antineoplastic Agents III, Antimitotic Drugs

Question 1

*Vinca alkaloids (class), Members (Vinblastine, vincristine, vinorelbine) MOA and what phase does the drug work in?

Answer 1

• INHIBIT TUBULIN POLYMERIZATION–BLOCK ASSEMBLY of microtubules
• M-PHASE

Question 2

*Taxanes (class), Members (Taxol(Paclitaxel) and taxotere (Doccetaxel)) MOA and what phase does the drug work in?

Answer 2

• ENHANCE TUBULIN POLYMERIZATION–STABILIZE microtubules
• “Taxes stabalize”
• M-phase

Question 3

Epothilones (class), members Ixabepilone MOA and what phase does the drug work in?

Answer 3

• Same as Taxanes: ENHANCE tubulin polymerization–STABALIZE microtubules
• M-phase

Question 4

*Vinblastine Uses

Answer 4

TESTICULAR CANCER (with bleomycin and cisplatin), lymphomas, neuroblastoma

Question 5

*Vincristine Uses

Answer 5

-More pediatric uses: WILM’S AND EWINGS SARCOMA, ALL, lymphoma, neuroblastoma,

Question 6

Vinorelbine uses

Answer 6

-NSCL cancer (alone or with cisplatin)

Question 7

Paclitaxel uses

Answer 7

-Advance breast/ovarian cancer (with cisplatin)

Question 8

Docetaxel uses

Answer 8

-Advance breast/ovarian cancer, solid tumors (low yield?)

Question 9

Epothilone Uses

Answer 9

-Resistant breast cancer (alone or with capecitabine)

Question 10

Vinblastine Dose limiting Toxicity

Answer 10

• Bone marrow suppression

- Vesicant blisters

Question 11

Vincristine Dose limiting Toxicity

Answer 11

• Neurotoxicity
• Peripheral neuropathy
• Paralytic ileus
• Vesicant -blisters

Question 12

Vinorelbine Dose limiting Toxicity

Answer 12

• Bone marrow suppression

- Vesicant -blisters

Question 13

Paclitaxel Dose limiting Toxicity

Answer 13

• Bone marrow suppression, Peripheral neuropathy

- Hypersensitivity during infusion:anti-histamine needed and corticosteroid pretreatment

Question 14

Docetaxel Dose limiting Toxicity

Answer 14

-Neutropenia, Peripheral neuropathy

Question 15

Epothilone Dose limiting Toxicity

Answer 15

• Myelosuppression, peripheral neuropathy

- hypersensitivity

Question 16

Vanco, taxanes, epothilone resistance developed how?

Answer 16

-P-glycoprotein transporter or by tubulin mutation