Pharm 5-Sympathetic Inhibition Flashcards
Name the a1 selective blockers
“-osin.” Prazosin, terazosin, doxazosin, tamsulosin.
Name the application sof a1 blockers
HTN and urinary retention in BPH
a1 blocker toxicities
1st dose orthostatic hypotension; dizziness, headache, hypotension -> tachycardia
Unique feature of tramsulosin
Selective for a1A receptor which is only found in prostate tissue
Name the nonselective a-blockers
Phenozybenzamine (irreversible) and Phentolamine (reversible)
Applications of phenoxybenzamine?
Pheochromocytoma since high levels of CA will not be able to overcome blockage
Side effects of phenoxybenzamine
Orthostatic hypotension, reflexy tachycardia
Uses of phentolamine
Pts on MAO inhibitors who eat tyramine-containing foods
Uses of B-blockers
Angina, MI, SVT, HTN, CHF, Glaucoma
Toxicity of B-blockers
ED, exacerbate asthma, bradycardia, AV block, CNS adverse effects (seizures, sedation, sleep alts), increase glycose, hide sx of hypoglycemia
Populations who should use B-blockers w/ caution
Asthmatics, COPD, acute/uncontrolled CHF, diabetics
Do you give B-blockers w/ cocain? Why or why not?
No bc it will lead to unopposed a1 -> vasoconstriction
List the B1-selective antagonists
A-M end in olol. Acebutolol, Betaxolool, Esmolol (short-acting), Atenolol, Metoprolol.
List the nonselective B-blockers
N-Z end in olol. Propranolol, Timolol, Nadolol, Pindolol
List the alpha and beta blockers
Carvedilol and Labetalol
