Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

DIT > Immuno 8 > Flashcards

Immuno 8 Flashcards

1
Q

Examples of HSN Type 1?

A

Anaphylaxis, allergic and atopic disorders

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Examples of Type II HSN rxns?

A

Autoimmune hemolytic anemia, pernicious anemia, idiopathic thrombocytopenia purpura, erythroblastosis fetalis, acute hemolytic transfusion rxns, RF, goodpasture’s, bullous pemphigoid, pemphigus vulgaris

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Examples of Type III HSN rxn

A

SLE, polyarteritis nodosa, postretptococcal glomerulonephritis, serum sickness, arthus rxn (ex after tetanus vaccine)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Exmaples of Type IV HSN rxn?

A

MS, guillain-barre, graft vs. host, PPD (for TB), contact dermatitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

High points about Type I HSN?

A

Antigen, IgE, Mast cell, Basophils, histmaine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

High points of Type II HSN?

A

Anti-self antibody (cytotoxic ie. antibody mediated)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

High points of Type III HSN rxn?

A

Antibody against antigen that deposits in tissue (ie. immunecomplex)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

High points of Type IV HSN rxn?

A

Delayed (T-cell mediated)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the 3 ways to activate complemetn?

A
  1. Alternative. 2. Lectin. 3. Classic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the starting point of classic pwy?

A

C1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the important end-product of complement pwy?

A

MAC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Functions of C3a and C5a?

A

Anaphylaxis. C3a stim mast cells and basophils to rel histamine and C5a= neut chemotaxis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Function of C5b-C9?

A

MAC -> cytolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Defy of C1 esterase inhibitor leads to?

A

Hereditary angioedema due to inc bradykinin. DO NOT give ACE inhib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Defy of C3 leads to?

A

Secere recurrent pyogenic sinus and resp infections w/ Strep pneumoniae and H. influenzae. Inc susceptibility to Type III HSN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Defy of C5-C9 leads to?

A

recurrent Neisseria bacteremia

17
Q

Defy of DAF (CD55) leads to?

A

complement-mediated lysis of RBCs and Paxoxysmal nocturnal hemoglobinuria (PNH)

18
Q

What is deficient in Paroxysmla Nocturnal Hemoglobinuria?

A

GPI (anchors CD55) and CD59 (prevents MAC)

19
Q

Characteristics/Pres of PNH?

A

Chronic intravascular hemolysis -> hemosidinuria -> iron dey anemia. Thrombosis

20
Q

How to dx PNH?

A

Ham’s test and flow cytometry

21
Q

Rx for PNH?

A

Iron supp, warfarin, BM transplant

DIT (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions