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DIT > Immuno 7 WOW > Flashcards

Immuno 7 WOW Flashcards

1
Q

MOA of cyclosporine?

A

Binds to cyclophilins. Complex blocks the dfiferentiation and activation of T cells by inhibiting calcineurin (usually activates transcription of IL-2) -> prevents formation of IL-2.

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2
Q

Toxicity of cyclosporine?

A

Neprhotoxicity and HTN

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3
Q

MOA of Tacrolimus?

A

Binds to FK-binding protein -> inibits calcineurin and prevents secretion of IL-2

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4
Q

Toxicity of Tacrolimus?

A

Nephrotoxicity, HTN, Neurotoxicity

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5
Q

MOA of Sirolimus (rapamycin)?

A

Binds FKBP-12 -> inhibits mTOR (mammalian target of rapamycin) -> inhibition of T-cell prolif.

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6
Q

MOA of Azthioprine?

A

Antimetabolite precursor of 6-mercaptopurine that interferes w/ the metab and synth of nucleic acids. Toxic to lymphocytes

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7
Q

Toxicity of Azathioprine?

A

Bone marrow suppression bc can’t make rapidly divding cells.

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8
Q

How is Azathioprine metabolized? What does that mean?

A

Metabolized by xanthine oxidase thus, toxic effects may be increased by allopurinol

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9
Q

MOA of Muromonab?

A

Monoclonal antibody that binds to CD3 on surface of T cells -> blocks cellular interaction w/ CD3 protein responsible for T-cell signal transduction

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10
Q

Toxicity of Muromonab?

A

Hypersensitivity rxn

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11
Q

MOA of Dicluzumab?

A

High affinity for IL-2 Receptors (CD25) on T-cells

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12
Q

MOA of Micofinolate?

A

Inhibits inosine monophosphate dehydrogenase -> no guanine can be made so no rapidly dividing cells can be made.

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13
Q

Uses of Micofinolate?

A

Transplant and Lupus nephritis

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14
Q

What are the Immunosuppressants used for transplants?

A

Cyclosporines, Tacrolimus, Sirolimus, Azathioprine, Murmonab, Dicluzumab, Micofinolate.

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15
Q

Muromonab target and use?

A

CD3. Prevent acute transplant rejection

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16
Q

Digoxin immune Fab target and use?

A

Digoxin. Antidote for digoxin intoxication

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17
Q

Infliximab, Adalimumab, Etanercept target and use?

A

TNF-a. Crohn’s, RA, seronegative arthritis (PAIR disease)

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18
Q

Abciximab target and use?

A

Glycoprotein Iib/IIIa on platelets. Prevent cardiac ischemia, unstable angina, after stent.

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19
Q

Trastuzumab target and use?

A

HER2. HER2-overexpressing breast cancer

20
Q

Rituximab target and use?

A

CD20. B-cell non-Hodgkin’s lymphoma

21
Q

Omalizumab target and use?

A

IgE. Sevre asthma

22
Q

Transplant rejection types?

A
  1. Hyperacute. 2. Acute. 3. Chronic. 4. Graft vs. Host. All on FA 208
23
Q

Aldesleukin: cytokine and use?

A

IL-2. Renal cell carcinoma and metastatic melanoma.

24
Q

Epoetin alfa: cytokine and use?

A

EPO. Anemias esp in renal failure

25
Q

Filgrastim and Sargramostim: cytokine and use?

A

IL-3 and granulocyte-CSF. Recovery of BM

26
Q

a-IFN use

A

Hepatitis B and C, Kaposi sarcoma, leukemias, malignant melanoma

27
Q

B-IFN use

A

multiple sclerosis

28
Q

gamma-IFN use

A

chornic granulomatous disease. Optimize MO and phagocytes

29
Q

Oprelvekin: cytokine and use?

A

IL-11. Thrombocytopenia

30
Q

Thrombopoietin use?

A

Thrombocytopenia

31
Q

Cytokines secretd by MO?

A

IL-1, IL-6, IL-8 (CXCL8), IL-12, TNF-a

32
Q

Cytokines secreted by all T-cells?

A

Il-2 and IL-3

33
Q

Cytokines secreted from Th1 cells?

A

IFN-gamma

34
Q

Cytokines secretd by Th2 cells?

A

IL-4, IL-5, IL-10

35
Q

Cytokine that promotes B cell growth and differentiation?

A

IL-4 and IL-5

36
Q

Function of IL-5?

A

Promotes differentiation of B cells. Stimulates growth of eosinophils. Enhances class-switching to IgA. “snot producer”

37
Q

Fever inducing cytokines?

A

IL-1, IL-6, TNF-a

38
Q

Function of IL-10?

A

Inhibits actions of T cells, Th1 cells, and MO

39
Q

Function of IL-4?

A

Induces differentiation into Th2 cells, promotes growth of B-cells, enhances class switching to IgE and IgG

40
Q

Fucnction of IFN-gamma?

A

Activates MO and Th1 cells. Suppresses Th2 cells.

41
Q

Function of IL-2?

A

Stimulates growth of helper, cytotoxic, and regulatory T cells

42
Q

Function of IL-3?

A

Spports growth and differentiation of BM stem cells. Functions like GM-CSF

43
Q

Function of IL-8?

A

Cemotactic factor for neutrohils

44
Q

Chemotactic factors for neutrophils?

A

IL-8, C5a, LTB4

45
Q

Functnio of IL-12?

A

Induces differentiation of T cells into Th1 cells. Activates NK cells. Secreted by B cells too

46
Q

Function of TNF-a

A

Mediates SEPTIC SHOCK and causes leukocyte recruitment

DIT (14 decks)

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